Doxpicomine

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Doxpicomine
File:Doxpicomine.png
Systematic (IUPAC) name
1-(1,3-dioxan-5-yl)-N,N-dimethyl-1-pyridin-3-ylmethanamine
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
CAS Number 69494-04-8
ATC code none
PubChem CID ?
Chemical data
Formula C12H18N2O2
Molar mass 222.283 g/mol[[Script error: No such module "String".]]
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Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug, acting as a mu-opioid receptor agonist.[1] It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg meperidine.[2][3] It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.[4]

References

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Opioids
See also: Opioids template
Opium & alkaloids thereof
Semi-synthetic opium
derivatives
Synthetic opioids
Pyrazolones
Cannabinoids
Anilides
Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class
Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, Adjuvant & Potentiators,
Metabolic agents and miscellaneous
  1. ↑ Smits, SE; Nickander, R; Booher, RN; Zimmerman, DM; Wong, DT; Hynes, MD; Pohland, A (1981). "Preclinical pharmacology of doxpicodin, a new analgesic". NIDA research monograph. 34: 75–81. PMID 6261137.  edit
  2. ↑ Wang, RI; Robinson, N (1981). "Doxpicomine in postoperative pain". Clinical pharmacology and therapeutics. 29 (6): 771–5. doi:10.1038/clpt.1981.109. PMID 7014073.  edit
  3. ↑ Wang, RI; Robinson, N (1983). "Further efficacy evaluation of doxpicomine for postoperative pain". Journal of clinical pharmacology. 23 (1): 44–7. PMID 6341416.  edit
  4. ↑ Wünsch, B; Bauschke, G (1993). "Benzomorphan analogs with doxpicomine partial structure: synthesis and psychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines". Archiv der Pharmazie. 326 (3): 171–80. PMID 8481096.  edit
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