C-8813

From Self-sufficiency
Jump to: navigation, search
C-8813
200px
Systematic (IUPAC) name
trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
Legal status
Legal status
  • Legal
Identifiers
PubChem CID 11058633
Chemical data
Formula C20H26BrNOS
Molar mass 408.394 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

C-8813 is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans isomer was found to be around 591x more potent than morphine in animal studies.[1]

C-883 is claimed to be similarly potent at the δ-opioid receptor.[1]

Considering that C-883 is said to only be thrice the potency of μ-selective fentanyl, it is somewhat strange that bromadol is said to be 10,000 times the potency of morphine.

Clearly the thiophene is uglier****[uglier? this needs to be changed. maybe also use of the word "strange" in the line above too.] but it is suggestive of the possibility that the 10,000 figure quoted by Lednicer should be re-examined.

C-8813 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


40px This analgesic-related article is a stub. You can help ssf by expanding it.
  1. ↑ 1.0 1.1 Liu, ZH; Jin, WQ; Dai, QY; Chen, XJ; Zhang, HP; Chi, ZQ (2003). "Opioid activity of C8813, a novel and potent opioid analgesic". Life sciences. 73 (2): 233–41. doi:10.1016/S0024-3205(03)00263-7. PMID 12738037.  edit
Retrieved from "http://ssf.f15ijp.com/wiki/index.php?title=C-8813&oldid=27199"