|Systematic (IUPAC) name|
4,5α-epoxy- 3-hydroxy- 14β-pentylamino- 17-methyl- 7,8-didehydro- morphinan- 6-one
|Molar mass||368.469 g/mol[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
Pentamorphone (14β-pentylaminomorphinone, RX-77989) is a semi-synthetic opiate derivative related to compounds such as morphine, hydromorphone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action. It was found to produce relatively little respiratory depression compared to other potent opioid agonists, but its analgesic effects were somewhat disappointing in human trials, and while pentamorphone had some slight advantages over fentanyl these were not sufficient to warrant its introduction into clinical use.
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- Rudo FG, Wynn RL, Ossipov M, Ford RD, Kutcher BA, Carter A, Spaulding TC. Antinociceptive activity of pentamorphone, a 14-beta-aminomorphinone derivative, compared to fentanyl and morphine. Anesthesia and Analgesia. 1989 Oct;69(4):450-6. PMID 2476953
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