Ciramadol

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Ciramadol
File:Ciramadol.png
Systematic (IUPAC) name
3-[(R)-dimethylamino-[(1R,2R)-2-hydroxycyclohexyl]methyl]phenol
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 63269-31-8
ATC code none
PubChem CID 44463
Synonyms Ciramadol, WY-15705
Chemical data
Formula C15H23NO2
Molar mass 249.349 g/mol[[Script error: No such module "String".]]
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Ciramadol (WY-15,705) is an opioid analgesic that was developed in the late 1970s and is related to tramadol, tapentadol and venlafaxine.[1] It is a mixed agonist-antagonist for the μ-opioid receptor with relatively low abuse potential[2] and a ceiling on respiratory depression[3] which makes it a relatively safe drug. It has a slightly higher potency and effectiveness as an analgesic than codeine,[4] but is weaker than morphine.[5] Other side effects include sedation and nausea but these are generally less severe than with other similar drugs.[6]

See also

References

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Opioids
See also: Opioids template
Opium & alkaloids thereof
Semi-synthetic opium
derivatives
Synthetic opioids
Pyrazolones
Cannabinoids
Anilides
Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class
Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, Adjuvant & Potentiators,
Metabolic agents and miscellaneous


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  1. ↑ Cochrane AD, Bell R, Sullivan JR, Shaw J. Ciramadol. A new analgesic. Medical Journal of Australia. 1979 Nov 3;2(9):501-2.
  2. ↑ Preston KL, Bigelow GE, Liebson IA. Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. Journal of Pharmacology and Experimental Therapeutics. 1987 Mar;240(3):900-10.
  3. ↑ Romagnoli A, Keats AS. Low ceiling respiratory depression by ciramadol. International Journal of Clinical Pharmacology Research. 1986;6(6):451-5.
  4. ↑ Downing JW, Brock-Utne JG, Holloway AM. Ciramadol - a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. South African Medical Journal. 1983 Dec 10;64(25):978-82.
  5. ↑ Powell WF. A double-blind comparison of multiple intramuscular doses of ciramadol, morphine, and placebo for the treatment of postoperative pain. Anesthesia and Analgesia. 1985 Nov;64(11):1101-7.
  6. ↑ Stambaugh JE Jr, McAdams J. Comparison of the analgesic efficacy and safety oral ciramadol, codeine, and placebo in patients with chronic cancer pain. Journal of Clinical Pharmacology. 1987 Feb;27(2):162-6.
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