Ciramadol

From Self-sufficiency
Jump to: navigation, search
Ciramadol
File:Ciramadol.png
Systematic (IUPAC) name
3-[(R)-dimethylamino-[(1R,2R)-2-hydroxycyclohexyl]methyl]phenol
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number 63269-31-8
ATC code none
PubChem CID 44463
Synonyms Ciramadol, WY-15705
Chemical data
Formula C15H23NO2
Molar mass 249.349 g/mol[[Script error: No such module "String".]]
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Ciramadol (WY-15,705) is an opioid analgesic that was developed in the late 1970s and is related to tramadol, tapentadol and venlafaxine.[1] It is a mixed agonist-antagonist for the μ-opioid receptor with relatively low abuse potential[2] and a ceiling on respiratory depression[3] which makes it a relatively safe drug. It has a slightly higher potency and effectiveness as an analgesic than codeine,[4] but is weaker than morphine.[5] Other side effects include sedation and nausea but these are generally less severe than with other similar drugs.[6]

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />



  1. Jump up Cochrane AD, Bell R, Sullivan JR, Shaw J. Ciramadol. A new analgesic. Medical Journal of Australia. 1979 Nov 3;2(9):501-2.
  2. Jump up Preston KL, Bigelow GE, Liebson IA. Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. Journal of Pharmacology and Experimental Therapeutics. 1987 Mar;240(3):900-10.
  3. Jump up Romagnoli A, Keats AS. Low ceiling respiratory depression by ciramadol. International Journal of Clinical Pharmacology Research. 1986;6(6):451-5.
  4. Jump up Downing JW, Brock-Utne JG, Holloway AM. Ciramadol - a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. South African Medical Journal. 1983 Dec 10;64(25):978-82.
  5. Jump up Powell WF. A double-blind comparison of multiple intramuscular doses of ciramadol, morphine, and placebo for the treatment of postoperative pain. Anesthesia and Analgesia. 1985 Nov;64(11):1101-7.
  6. Jump up Stambaugh JE Jr, McAdams J. Comparison of the analgesic efficacy and safety oral ciramadol, codeine, and placebo in patients with chronic cancer pain. Journal of Clinical Pharmacology. 1987 Feb;27(2):162-6.