From Self-sufficiency
Jump to: navigation, search
Systematic (IUPAC) name
(2R,6R,11R)- 6,11-dimethyl- 3-prop- 2-en- 1-yl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol 2-allyl- 5,9-dimethyl- 2'-hydrox​y- 6,7-benzo​morphan
Clinical data
Routes of
Legal status
Legal status
  • Uncontrolled
CAS Number 14198-28-8
ATC code none
PubChem CID 3036246
ChemSpider 2300306
Chemical data
Formula C17H23NO
Molar mass 257.37 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Alazocine ((-)-SKF-10,047), or (-)-N-allylnormetazocine ((-)-ANMC), was the first drug discovered to act as a σ1 receptor agonist (Ki = 24 nM).[1][2][3] It has no significant affinity for the σ2 receptor.[3] Alazocine also acts as a κ-opioid receptor agonist (Ki = 0.4 nM), and to a much lesser extent, as an NMDA receptor antagonist (Ki = 587 nM).[4][3]

See also


Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

  1. Iwamoto ET. Pharmacologic effects of N-allylnormetazocine (SKF-10047). NIDA Research Monographs. 1981 Feb;34:82-8. PMID 6783955
  2. Shearman GT, Herz A. Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat. European Journal of Pharmacology. 1982 Aug 27;82(3-4):167-72. PMID 6290235
  3. 3.0 3.1 3.2 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (2006). "Pharmacological profiles of opioid ligands at kappa opioid receptors". BMC Pharmacology. 6: 3. doi:10.1186/1471-2210-6-3. PMC 1403760Freely accessible. PMID 16433932.