Nicodicodeine
From Self-sufficiency
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| 180px | |
| Systematic (IUPAC) name | |
|---|---|
|
(5α,6α)-3-methoxy- 17-methyl- 4,5-epoxymorphinan- 6-yl nicotinate | |
| Clinical data | |
| Routes of administration | Oral, intravenous |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | 808-24-2 |
| ATC code | none |
| PubChem | CID 5464304 |
| Synonyms | 6-Nicotinoyldihydrocodeine |
| Chemical data | |
| Formula | C24H26N2O4 |
| Molar mass | 406.474 g/mol[[Script error: No such module "String".]] |
Nicodicodeine is an opiate derivative developed as a cough suppressant and analgesic. Synthesized in 1904, it is not commonly used, but has activity similar to other opiates. Nicodicodeine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodeine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression.
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