NNC 63-0532
From Self-sufficiency
Revision as of 21:23, 18 August 2010 by Edgar181 (Talk) (Removed Category:Acetates; Adding category Category:Methyl esters (using HotCat))
| 200px | |
| Systematic (IUPAC) name | |
|---|---|
|
methyl [8-(1-naphthylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl)acetate | |
| Identifiers | |
| CAS Number | 250685-44-0 |
| PubChem | CID 9803475 |
| Synonyms | NNC 63-0532 |
| Chemical data | |
| Formula | C27H29N3O3 |
| Molar mass | 443.536 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
NNC 63-0532 is an opioid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 receptor.[1][2] The function of this receptor is still poorly understood, but it is thought to have roles in many disorders such as pain, drug addiction, development of tolerance to opioid drugs, and psychological disorders such as anxiety and depression. Research into the function of this receptor is an important focus of current pharmaceutical development and selective agents such as NNC 63-0532 are essential for this work.[3]
 |
This pharmacology-related article is a stub. You can help ssf by expanding it. |
References
- ↑ Thomsen C, Hohlweg R. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. British Journal of Pharmacology. 2000 Nov;131(5):903-8. PMID 11053209
- ↑ Guerrini R, Carra' G, Calo' G, Trapella C, Marzola E, Rizzi D, Regoli D, Salvadori S. Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity. Journal of Peptide Research. 2004 Jun;63(6):477-84. PMID 15175020
- ↑ Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications. Current Drug Targets. 2007 Jan;8(1):117-35. PMID 17266536
Categories:
- Pages with script errors
- Pages with broken file links
- Infobox drug tracked parameters
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Pharmacology stubs
- Opioids
- Naphthalenes
- Piperidines
- Lactams
- Nitrogen heterocycles
- Methyl esters
- 2Fix
