SC-17599
From Self-sufficiency
| 200px | |
| Systematic (IUPAC) name | |
|---|---|
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6-[(dimethylamino)methyl]-3-ethoxy-21-fluoro-20-oxopregna-3,5-dien-17-yl acetate | |
| Legal status | |
| Legal status |
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| Identifiers | |
| PubChem | CID 10436424 |
| Synonyms | SC-17599, 17α-Acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3,5-dien-20-one, [(8R,9S,10R,13S,14S,17R)-6-(dimethylaminomethyl)-3-ethoxy-17-(2-fluoroacetyl)-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
| Chemical data | |
| Formula | C28H42FNO4 |
| Molar mass | 475.634 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
SC-17599 is a steroid derivative drug discovered in 1968 which acts as a selective μ-opioid receptor agonist, with little or no affinity for the δ-opioid or κ-opioid receptors. It is an active analgesic in vivo, more potent than codeine or pethidine but slightly less potent than morphine,[1] and produces similar effects to morphine in animals but with less sedation.[2][3]
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References
- ↑ Craig CR. Analgetic Activity and Other Pharmacological Properties of a Steroid; 17α-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one Hydrochloride (SC17599) Journal of Pharmacology And Experimental Therapeutics 1968; 164(2):371-379.
- ↑ McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. Molecular Pharmacology. 2000 Oct;58(4):669-76. PMID 10999935
- ↑ Houshyar H, Mc Fadyen IJ, Woods JH, Traynor JR. Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor. European Journal of Pharmacology. 2000 Apr 28;395(2):121-8. PMID 10794817
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