Sinomenine

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Sinomenine
File:Sinomenine.png
Systematic (IUPAC) name
(+)-4-hydroxy- 3,7-dimethoxy- 17-methylmorphin- 7-en- 6-one
Identifiers
CAS Number 115-53-7
ATC code none
PubChem CID 5459308
Chemical data
Formula C19H23NO4
Molar mass 329.390 g/mol[[Script error: No such module "String".]]
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Sinomenine or Cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]

See also

References

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  1. ↑ Zhao ZZ, Liang ZT, Zhou H, Jiang ZH, Liu ZQ, Wong YF, Xu HX, Liu L. Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method. Biological and Pharmaceutical Bulletin. 2005 Jan;28(1):105-9. PMID 15635172
  2. ↑ Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Medica Okayama. 1976 Feb;30(1):1-20. PMID 61710
  3. ↑ Liu L, Riese J, Resch K, Kaever V. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. Arzneimittelforschung. 1994 Nov;44(11):1223-6. PMID 7848335
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