Difference between revisions of "Conivaptan"

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Conivaptan
202px
Systematic (IUPAC) name
N-(4-(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin- 6(1H)-yl)carbonyl)phenyl)- (1,1'-biphenyl)-2-carboxamide
Clinical data
Routes of
administration		 intravenous
Pharmacokinetic data
Bioavailability N/A
Identifiers
CAS Number 210101-16-9
ATC code C03XA02 (WHO) [1]
PubChem CID 151171
ChemSpider 133239
Chemical data
Formula C32H26N4O2
Molar mass 498.583[[Script error: No such module "String".]]
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Conivaptan (YM 087, brand name Vaprisol) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH), and there is some evidence it may be effective in heart failure. It is marketed by Astellas Pharma Inc.

Conivaptan inhibits two of the three subtypes of the vasopressin receptor (V1a and V2). Effectively, it causes iatrogenic nephrogenic diabetes insipidus.

Conivaptan has not been approved by the FDA for the treatment of decompensated congestive heart failure. However, in theory, vasopressin receptor antagonism would be particularly useful in this setting, and an initial study shows that it has some promise.[2]

References

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Sulfonamides
(except EA)
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
Osmotic diuretics (PT, DL)
VAs (DCT and CD)
Other
Hypothalamic
Agonists: Lanreotide · Octreotide
Anterior pituitary
Agonists: Thyrotropin
Posterior pituitary
Agonists: Carbetocin · Demoxytocin
Antagonists: Atosiban


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  1. ↑ WHO International Working Group for Drug Statistics Methodology (August 27, 2008). "ATC/DDD Classification (FINAL): New ATC 5th level codes". WHO Collaborating Centre for Drug Statistics Methodology. Retrieved 2008-09-05. 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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