Enkephalinase
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Enkephalinases are enzymes which degrade endogenous enkephalin opioid peptides. They include:[1]
- Aminopeptidase N (APN)
- Neutral endopeptidase (NEP)
- Dipeptidyl peptidase 3 (DPP3)
Enkephalinase inhibitors (EIs) include BL-2401, RB-101, RB-120, RB-3007, D-phenylalanine, racecadotril (acetorphan), thiorphan, ketalorphan, and ubenimex, as well as the endogenous compounds spinorphin and opiorphin.[1] They have analgesic, antidepressant, anxiolytic, and antidiarrheal effects.[1]
See also
References
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| Topics | |
|---|---|
| Types | EC1 Oxidoreductases/list · EC2 Transferases/list · EC3 Hydrolases/list · EC4 Lyases/list · EC5 Isomerases/list · EC6 Ligases/list |
| Class | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Substrate |
| ||||||||
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