Propylnorapomorphine

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Propylnorapomorphine
File:Propylnorapomorphine.svg
Systematic (IUPAC) name
(6aS)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 57559-68-9
ATC code none
PubChem CID 5311191
ChemSpider 4470712
Chemical data
Formula C19H21NO2
Molar mass 295.38 g/mol[[Script error: No such module "String".]]
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N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine.[1][2] It rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among other effects.[3][4][5][6] Notably, its effects on locomotion are biphasic, with low doses producing inhibition and catalepsy and high doses resulting in enhancement of activity.[7] This is likely due to preferential activation of D2/D3 autoreceptors versus postsynaptic receptors,[8] the latter of which overpowers the former only with high doses.

See also

References

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