Spiperone

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Spiperone
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Systematic (IUPAC) name
8-[4-(4-fluorophenyl)-4-oxo-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Clinical data
Routes of
administration
Oral
Pharmacokinetic data
Metabolism Hepatic
Excretion Renal
Identifiers
CAS Number 749-02-0
ATC code none
PubChem CID 5265
IUPHAR/BPS 99
Chemical data
Formula C23H26FN3O2
Molar mass 395.47 g/mol[[Script error: No such module "String".]]
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Spiperone (Spiroperidol, Spiropitan) is a psychoactive drug and research chemical belonging to the butyrophenone chemical class.[1] It functions as a 5-HT1A, 5-HT2A, 5-HT7, and D2 receptor antagonist, and has been used to identify these receptors when labeled with tritium. It has negligible affinity for the 5-HT2C receptor. Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl- channels (CaCCs), thus a potential target for therapy of cystic fibrosis.[2]

N-Methylspiperone (NMSP) is a derivate of spiperone that is used to study the dopamine and serotonin neurotransmitter system. Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.[3]

References

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ja:スピペロン
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