NS-2359

NS-2359
	File:NStwothreefivenine.png
Systematic (IUPAC) name
	(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-azabicyclo[3.2.1]octane
Identifiers
ATC code	none
PubChem	CID 11408320
Chemical data
Formula	C15H19Cl2NO
Molar mass	300.223 g/mol[[Script error: No such module "String".]]
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NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepressant,^[1] but was discontinued in 2009 when phase II clinical trials turned up disappointing results and did not support further effort by the company.^[1] NS-2359 was also in clinical trials for the treatment of ADHD,^[2] phase II having been completed in 2007.^[3] A trial exploring the effect of NS-2359 on cocaine-experienced individuals is currently ongoing.^[4]

References

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35px	This drug article relating to the nervous system is a stub. You can help ssf by expanding it. v d e

v t e Phenyltropanes (classifications)
2-Carboxymethyl Esters	Troparil • WIN 35428 • RTI-31 • RTI-32 • RTI-51 • RTI-55
(3,4-Disubstituted Phenyl)-tropanes	Dichloropane • RTI-112 • RTI-353
Arylcarboxy	RTI-113
Carboxyalkyl	RTI-121 • RTI-150
Acyl	PTT/WF-11 • WF-23 • PIT/WF-21 • WF-33
β,α Stereochemistry	RTI-352 • RTI-274
α,β Stereochemistry	Brasofensine • Tesofensine • NS2359
Heterocycles: 3-Substituted-isoxazol-5-yl	RTI-177 • RTI-336 • RTI-371
Heterocycles: 3-Substituted-1,2,4-oxadiazole	RTI-126 • RTI-371
N-alkyl	FP-β-CPPIT • FE-β-CPPIT • Altropane • Ioflupane (¹²³I)
N-replaced (S,O,C)	Tropoxane
Irreversible	RTI-76
Nortropanes (N-demethylated)	NS2359 (GSK-372,475)