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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 132810-10-7
ATC code none
PubChem CID 125564
ChemSpider 111697
Chemical data
Formula C23H30FN3
Molar mass 367.50 g/mol[[Script error: No such module "String".]]
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Blonanserin (Lonasen) is a relatively new atypical antipsychotic commercialized by Dainippon Sumitomo Pharma in Japan and Korea for the treatment of schizophrenia.[1][2][3] Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms and excessive sedation and hypotension.[3]

Blonanserin acts as a mixed 5-HT2 (Ki = 3.98 nM) and D2 receptor (Ki = 14.8 nM) antagonist.[4] It also exerts some blockade of α1-adrenergic receptors (Ki = 56.3 nM) and has low affinity for the sigma receptor (IC50 = 286 nM).[4] Blonanserin lacks significant affinity for numerous other sites including 5-HT1, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, mACh, and the monoamine transporters.[4]

See also


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  2. Garcia E, Robert M, Peris F, Nakamura H, Sato N, Terazawa Y (2009). "The efficacy and safety of blonanserin compared with haloperidol in acute-phase schizophrenia: a randomized, double-blind, placebo-controlled, multicentre study". CNS Drugs. 23 (7): 615–25. PMID 19552488. 
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