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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 13862-07-2
ATC code none
PubChem CID 65607
ChemSpider 59048
Chemical data
Formula C20H25NO
Molar mass 295.42 g/mol[[Script error: No such module "String".]]
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Difemetorex (INN; sold as Cleofil), also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use.[1][2][3][4][5] It was introduced in France by Ciba-Geigy in 1966 but is now no longer marketed.[6]

See also


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  1. Isbell H, Chrusciel TS. Dependence Liability of Non-Narcotic Drugs. Bulletin of the World Health Organisation 1970; 43: Supplement.
  2. Stepanek J, Zolliker VR. Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex. Archives Internationales de Pharmacodynamie et de Therapie. (German). 1971 Jun;191(2):376-99. PMID 5089225
  3. Stepanek J. Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex. Archives Internationales de Pharmacodynamie et de Therapie. (German). 1972 Sep;199(1):122-38. PMID 5072180
  4. Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. ISBN 0-7514-0499-3. 
  5. "The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved 03-23-2010.  Check date values in: |access-date= (help)
  6. Brudon, Pascale (1983). Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. France: Editions d'En bas. p. 207. ISBN 2-8290-0039-0.