Vesicular monoamine transporter

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The vesicular monoamine transporter (aka VMAT) is a transport protein integrated into the membrane of intracellular vesicles of presynaptic neurons. It acts to transport monoamines into the synaptic vesicles.


The two isoforms are:


Substrates for the transporter are mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+.[1]

Clinical significance

VMAT can be inhibited by reserpine, tetrabenazine[1] and ibogaine[2].

VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransmitter release that is not dependent on the phasic activity of the presynaptic cell.


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Further reading

External links

ru:Везикулярный транспортер моноаминов
  1. 1.0 1.1 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 167
  2. "The Ibogaine Dossier. Pharmacology of Ibogaine".