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Systematic (IUPAC) name
(1R,2S,3S)-methyl 3-(4-chloro-3-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
PubChem CID 9904673
Chemical data
Formula C17H22ClNO2
Molar mass 307.82 g/mol[[Script error: No such module "String".]]
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RTI-112 (2β-carbomethoxy-3β-(3-methyl-4-chlorophenyl)tropane) is a synthetic stimulant drug from the phenyltropane family. In contrast to RTI-113 which is DAT selective, RTI-112 is a nonselective triple reuptake inhibitor.[1]

The in vitro tests actually show a very similar DAT/SERT/NET selectivity to cocaine,[2] although in vivo they behave differently.

"the nonselective monoamine transporter inhibitor RTI-126 and the DAT-selective inhibitors RTI-150 and RTI-336 both had a faster rate of onset (30 min) and a short duration of action (4h). In contrast, the nonselective monoamine transporter inhibitor RTI-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). The DAT-selective inhibitors RTI-171 and RTI-177 also had slower rates of onset (30–120 min), but RTI-171 had a short duration of action (2.5 h) while RTI-177 had a very long duration of action (20 h)."[3]

The efficacy of cocaine analogs to elicit self administration is related to the rate at which they are administered.

Slower onset analogs are less likely to function as behavioral stimulants than analogs sporting a faster rate of onset.[4]

Nonselective analogs are less likely to function as "reinforcers" than reuptake inhibitors that have DAT specificity.[3]

In order for a DRI such as cocaine to induce euphoria PET scans on primates reveal that the DAT occupancy needs to be >60%.[5]

RTI-112 is a particularly interesting nonselective cocaine-analog that has equipotent in vitro affinity at the SERT, NET and DAT, respectively.[2]

RTI-112 was not reliably self-administered, in contrast to the DAT selective reuptake inhibitors that were used in this study.[2]

Particularly notable is the fact that in vivo at the ED50, RTI-112 had no DAT occupancy at all.[2]

At the ED50, (mostly) all of the RTI-112 occupied the SERT at this dose.[2]

Significantly higher dose was required to get >70% DAT occupancy in the case of RTI-112.[2]

However RTI-112 was still able to suppress cocaine administration at the ED50 suggesting a serotonergic mechanism was responsible for this.[2]


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  1. [1] Ginsburg, B.C., Kimmel, H.L., Carroll, F.I., Goodman, M.M., Howell, L.L. Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys. Pharmacology Biochemistry and Behavior, 80: 481-491, 2005.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 [2] Lindsey, K.P., Wilcox, K.M., Votaw, J.R., Goodman, M.M., Plisson, C., Carroll, F.I., Rice, K.C., Howell, L.L. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. Journal of Pharmacology and Experimental Therapeutics, 309: 959-969, 2004.
  3. 3.0 3.1 Kimmel HL, O'Connor JA, Carroll FI, Howell LL. Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. Pharmacol Biochem Behav. 2007 Jan;86(1):45-54. pmid 17258302
  4. [3] Wee S, Carroll FI, Woolverton WL. A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants. Neuropsychopharmacology. 2006 Feb;31(2):351-62.
  5. [4] Howell, L.L. and Wilcox, K.M. The dopamine transporter and cocaine medication development: Drug self-administration in nonhuman primates. Journal of Pharmacology and Experimental Therapeutics, 298: 1-6, 2001.