Difference between revisions of "Sumanirole"
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Latest revision as of 03:07, 11 July 2010
File:Suminarole.png | |
Systematic (IUPAC) name | |
---|---|
(R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one | |
Identifiers | |
CAS Number |
179386-43-7 179386-44-8 (maleate) |
ATC code | none |
PubChem | CID 9818479 |
ChemSpider | 7994229 |
Chemical data | |
Formula | C11H13N3O |
Molar mass | 203.240 g/mol[[Script error: No such module "String".]] |
Script error: No such module "collapsible list". |
Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered.[1][2][3] It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use [4][5] it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. [3]
See also
References
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- ↑ Romero AG, et al. Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy. Journal of Organic Chemistry. 1997; 62(19):6582.
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- Amines
- Dopamine agonists
- Imidazoles
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