Profadol

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Profadol
Systematic (IUPAC) name
200px
3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol
Legal status
Legal status	Uncontrolled
Identifiers
CAS Number	428-37-5
ATC code	none
PubChem	CID 9882
ChemSpider	9498
Chemical data
Formula	C₁₄H₂₁NO
Molar mass	219.32 g/mol[[Script error: No such module "String".]]

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Profadol is an opioid analgesic which was developed in the late 1960s. It acts as a mixed agonist-antagonist of the μ-opioid receptor.

References

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Analgesics (N02A, N02B)

Opioids
See also: Opioids template

Opium & alkaloids thereof	Codeine · Morphine · Opium · Laudanum · Paregoric
Semi-synthetic opium derivatives	Acetyldihydrocodeine · Benzylmorphine · Buprenorphine · Desomorphine · Dihydrocodeine · Dihydromorphine · Ethylmorphine · Diamorphine · Hydrocodone · Hydromorphinol · Hydromorphone · Nicocodeine · Nicodicodeine · Nicomorphine · Oxycodone · Oxymorphone
Synthetic opioids	Alphaprodine · Anileridine · Butorphanol · Dextromoramide · Dextropropoxyphene · Dezocine · Fentanyl · Ketobemidone · Levorphanol · Methadone · Meptazinol · Nalbuphine · Pentazocine · Propoxyphene · Propiram · Pethidine · Phenazocine · Piminodine · Piritramide · Tapentadol · Tilidine · Tramadol

Pyrazolones

Ampyrone/Aminophenazone · Metamizole · Phenazone · Propyphenazone

Cannabinoids

Ajulemic acid · AM404 · Cannabidiol · Cannabis · Nabilone · Nabiximols · Tetrahydrocannabinol

Anilides

Paracetamol (acetaminophen) · Phenacetin · Propacetamol

Non-steroidal
anti-inflammatories
See also: NSAIDs template

Propionic acid class	Fenoprofen · Flurbiprofen · Ibuprofen · Ketoprofen · Naproxen · Oxaprozin
Oxicam class	Meloxicam · Piroxicam
Acetic acid class	Diclofenac · Indometacin · Ketorolac · Nabumetone · Sulindac · Tolmetin
COX-2 inhibitors	Celecoxib · Rofecoxib · Valdecoxib · Parecoxib · Lumiracoxib
Anthranilic acid (fenamate) class	Meclofenamate · Mefenamic acid
Salicylates	Aspirin (Acetylsalicylic acid) · Benorylate · Diflunisal · Ethenzamide · Magnesium salicylate · Salicin · Salicylamide · Salsalate · Trisalate · Wintergreen (Methyl salicylate)

Atypical, Adjuvant & Potentiators,
Metabolic agents and miscellaneous

Amitryptiline · Befiradol · Bicifadine · Carisoprodol · Camphor · Cimetidine · Clonidine · Chlorzoxazone · Cyclobenzaprine · Duloxetine · Esreboxetine · Flupirtine · Gabapentin · Glafenine · Hydroxyzine · Ketamine · Menthol · Mephenoxalone · Methocarbamol · Nefopam · Orphenadrine · Pregabalin · Proglumide · Scopolamine · Tebanicline · Trazodone · XP-13512 (Gabapentin enacarbil) · Ziconotide

M: CNS

anat(s,m,p,4,e,b,d,c,a,f,l,g)/phys/devp/cell

noco(m,d,e,h,v,s)/cong/tumr,sysi/epon,injr

proc,drug(N1A/2AB/C/3/4/7A/B/C/D)

Opioids (N02A)

Opium and
Poppy straw
derivatives

Crude opiate extracts/
whole opium products

Compote/Kompot/Polish heroin · Diascordium · B & O Supprettes · Dover's powder · Laudanum · Mithridate · Opium · Paregoric · Poppy straw concentrate · Poppy tea · Smoking opium · Theriac

Natural Opiates

Opium Alkaloids see also: Components of Opium	Codeine · Morphine · Oripavine · Pseudomorphine · Thebaine
Alkaloid Salts Mixtures	Pantopon · Papaveretum (Omnopon) · Tetrapon

Semisynthetics

Morphine Family	2-(p-Nitrophenyl)-4-isopropylmorphine · 14-Hydroxymorphine · 14β-Hydroxymorphine · 14β-Hydroxymorphone · 2,4-Dinitrophenylmorphine · 6-Methyldihydromorphine · 6-Methylenedihydrodesoxymorphine · 6-Acetyldihydromorphine/6-Monoacetyldihydromorphine · Acetyldihydromorphine · Azidomorphine · Chlornaltrexamine · Dihydrodesoxymorphine (Desomorphine) · Dihydromorphine · Ethyldihydromorphine · Hydromorphinol · Methyldesorphine · N-Phenethylnormorphine · Pseudomorphine · RAM-378
3,6 Diesters of Morphine	6-acetyl-1-iodocodeine · 6-nicotinoyldihydromorphine · Acetylpropionylmorphine · Acetylbutyrylmorphine · Diacetyldihydromorphine (Dihydroheroin) · Diacetyldibenzoylmorphine · Dibutyrylcodeine · Dibutyrylmorphine · Dibenzoylmorphine · Diformylmorphine · Dipropanoylmorphine · Heroin (Diacetylmorphine) · Nicomorphine · Tetrabenzoylmorphine · Tetrabutyrylmorphine
Codeine-Dionine Family	14-Hydroxydihydrocodeine · Acetylcodeine · Benzylmorphine · Codeine methylbromide · Desocodeine · Dimethylmorphine (Methocodeine) · Methyldihydromorphine (Dihydroheterocodeine) · Ethylmorphine (Dionine) · Heterocodeine · Isocodeine · Isopropylmorphine · Morpholinylethylmorphine (Pholcodine) · Myrophine · Nalodeine · Transisocodeine
Morphinones & Morphols	1-Bromohydrocodone · 1-Bromooxycodone · 1-Chlorohydrocodone · 1-Chlorooxycodone · 1-Iodohydrocodone · 1-Iodooxycodone · 14-Cinnamoyloxycodeinone · 14-Ethoxymetopon · 14-Methoxymetopon · 14β-Hydroxymorphone · 14-O-Methyloxymorphone · 14-Phenylpropoxymetopon · 7-Spiroindanyloxymorphone · 8,14-Dihydroxydihydromorphinone · Acetylmorphinol · Acetylmorphone · α-hydrocodol · Bromoisopropropyldihydromorphinone · Codeinone · Codorphone · Codol · Codoxime · Thebacon (Acetyldihydrocodeinone / Dihydrocodeinone enol acetate) · Ethyldihydromorphinone · Hydrocodol · Hydrocodone · Hydromorphinone · Hydromorphol · Hydromorphone · Hydroxycodeine · Isopropropyldihydrocodeinone · Isopropropyldihydromorphinone · Methyldihydromorphinone · Metopon · Morphenol · Morphinol · Morphinone · Morphol · N-Phenethyl-14-ethoxymetopon · Oxycodone · Oxymorphol · Oxymorphinol · Oxymorphone · Pentamorphone · Semorphone
Morphides	α-chlorocodide (Alphachlorocodide/Chlorocodide) · α-chloromorphide · 3-Bromomorphide · Bromocodide · Bromomorphide (8-Bromomorphide) · Chlorocodide · Chloromorphide · · Codide · Fluorocodide (8-Fluorocodide) · Fluormorphide · Iodocodide · Iodomorphide (8-Iodomorphide) · Morphide
Dihydrocodeine Series	14-hydroxydihydrocodeine · Acetyldihydrocodeine · Dihydrocodeine · Dihydrodesoxycodeine/Desocodeine · Dihydroisocodeine · Nicocodeine · Nicodicodeine
Nitrogen Morphine Derivatives	1-Nitrocodeine · 2-Nitrocodeine · 1-Nitromorphine · 2-Nitromorphine · Codeine-N-Oxide · Heroin-N-Oxide · Hydromorphone-N-Oxide · Morphine-N-Oxide
Hydrazones	Acetylmorphazone · Hydromorphazone · Morphazone · Oxymorphazone
Halogenated Morphine Derivatives	1-Bromocodeine · 2-Bromocodeine · 1-Bromodiacetylmorphine · 2-Bromodiacetylmorphine · 1-Bromodihydrocodeine · 2-Bromodihydrocodeine · 1-Bromodihydromorphine · 2-Bromodihydromorphine · 1-Bromomorphine · 2-Bromomorphine · 1-Chlorocodeine · 2-Chlorocodeine · 1-Chlorodiacetylmorphine · 2-Chlorodiacetylmorphine · 1-Chlorodihydrocodeine · 2-Chlorodihydrocodeine · 1-Chlorodihydromorphine · 2-Chlorodihydromorphine · 1-Chloromorphine · 2-Chloromorphine · 1-Fluorocodeine · 2-Fluorocodeine · 1-Fluorodiacetylmorphine · 2-Fluorodiacetylmorphine · 1-Fluorodihydrocodeine · 2-Fluorodihydrocodeine · 1-Fluorodihydromorphine · 2-Fluorodihydromorphine · 1-Fluoromorphine · 2-Fluoromorphine · 3-Fluoromorphine · 1-Iodocodeine · 2-Iodocodeine · 1-Iododiacetylmorphine · 2-Iododiacetylmorphine · 1-Iododihydrocodeine · 2-Iododihydrocodeine · 1-Iododihydromorphine · 2-Iododihydromorphine · 1-Iodomorphine · 2-Iodomorphine · Chlorethylmorphine
Others	Pholcodine

Active Opiate
Metabolites

Codeine-N-Oxide (Genocodeine) · Dihydromorphine-6-glucuronide · Hydromorphone-N-Oxide · Heroin-7,8-Oxide · Morphine-6-glucuronide · 6-Acetylmorphine · Morphine-N-Oxide (Genomorphine) · Naltrexol · Norcodeine · Normorphine

Morphinans

Morphinan Series	4-chlorophenylpyridomorphinan · Cyclorphan · Dextrallorphan · Dimemorfan · Levargorphan · Levallorphan · Levorphanol · Levorphan · Levophenacylmorphan · Levomethorphan · Norlevorphanol · N-Methylmorphinan · Oxilorphan · Phenomorphan · Methorphan / Racemethorphan · Morphanol / Racemorphanol · Ro4-1539 · Stephodeline · Xorphanol
Others	1-Nitroaknadinine · 14-episinomenine · 5,6-Dihydronorsalutaridine · 6-Ketonalbuphine · Aknadinine · Butorphanol · Cephakicine · Cephasamine · Cyprodime · Drotebanol · Fenfangjine G · Nalbuphine · Sinococuline · Sinomenine (Cocculine) · Tannagine

Benzomorphans

5,9-DEHB · Alazocine · Anazocine · Bremazocine · Cogazocine · Cyclazocine · Dezocine · Eptazocine · Etazocine · Ethylketocyclazocine · Fluorophen · Ketazocine · Metazocine · Pentazocine · Phenazocine · Quadazocine · Thiazocine · Tonazocine · Volazocine · Zenazocine

4-Phenylpiperidines

Pethidines (Meperidines)	4-Fluoromeperidine · Allylnorpethidine · Anileridine · Benzethidine · Carperidine · Difenoxin · Diphenoxylate · Etoxeridine (Carbetidine) · Furethidine · Hydroxypethidine (Bemidone) · Hydroxymethoxypethidine · Morpheridine · Oxpheneridine (Carbamethidine) · Meperidine-N-Oxide · Pethidine (Meperidine) · Pethidine Intermediate A · Pethidine Intermediate B (Norpethidine) · Pethidine Intermediate C (Pethidinic Acid) · Pheneridine · Phenoperidine · Piminodine · Properidine (Ipropethidine) · Sameridine
Prodines	Allylprodine · Isopromedol · Meprodine (α-meprodine / β-meprodine) · MPPP (Desmethylprodine) · PEPAP · Prodine (α-prodine / β-prodine) · Prosidol · Trimeperidine (Promedol)
Ketobemidones	Acetoxyketobemidone · Droxypropine · Ketobemidone · Methylketobemidone · Propylketobemidone
Others	Alvimopan · Loperamide · Picenadol

Open Chain
Opioids

Amidones	Dextromethadone · Dextroisomethadone · Dipipanone · Hexalgon (Norpipanone) · Isomethadone · Levoisomethadone · Levomethadone · Methadone · Methadone intermediate · Normethadone · Norpipanone · Phenadoxone (Heptazone) · Pipidone
Methadols	Dimepheptanol (Racemethadol) · Levacetylmethadol · Noracetylmethadol
Moramides	Dextromoramide · Levomoramide · Moramide intermediate · Racemoramide
Thiambutenes	Diethylthiambutene · Dimethylthiambutene · Ethylmethylthiambutene · Piperidylthiambutene · Pyrrolidinylthiambutene · Thiambutene · Tipepidine
Phenalkoxams	Dextropropoxyphene (Propoxyphene) · Dimenoxadol · Dioxaphetyl Butyrate · Levopropoxyphene · Norpropoxyphene
Ampromides	Diampromide · Phenampromide · Propiram
Others	IC-26 · Isoaminile · Lefetamine · R-4066