Asimadoline

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Asimadoline
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Systematic (IUPAC) name
N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide
Identifiers
CAS Number 153205-46-0
PubChem CID 179340
Chemical data
Formula C27H30N2O2
Molar mass 414.539 g/mol[[Script error: No such module "String".]]
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Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid agonist.[1][2] Because of its poor ability to cross the blood-brain barrier, asimadoline lacks the psychotomimetic effects of centrally acting kappa agonists, and consequently has more potential for medical use, and has been researched as a possible treatment for irritable bowel syndrome, with reasonable efficacy seen in clinical trials.[3][4]

Synthesis

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References

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Drugs for
functional bowel disorders
Tertiary
amino group
Other
Belladonna and derivatives
(antimuscarinics)
tertiary amines: Atropine · Hyoscyamine
quaternary ammonium compounds: Scopolamine (Butylscopolamine, Methylscopolamine) · Methylatropine · Fentonium · Cimetropium bromide
Propulsives
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