Levocabastine

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Levocabastine
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Systematic (IUPAC) name
(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
Clinical data
Pregnancy
category
  • AU: B3
  • US: C (Risk not ruled out)
Routes of
administration		 Ophthalmic, intranasal[1]
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Biological half-life 3
Identifiers
CAS Number 79516-68-0
ATC code R01AC02 (WHO) S01GX02
PubChem CID 54385
IUPHAR/BPS 1586
DrugBank APRD01069
Chemical data
Formula C26H29FN2O2
Molar mass 420.519 g/mol[[Script error: No such module "String".]]
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Levocabastine is a selective second-generation H1-receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.[1]

As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS2, and was the first drug used to characterise the different neurotensin subtypes.[2][3] This has made it a useful tool for the study of this receptor.[4][5][6][7][8]

References

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  1. ^ "RxMed: Pharmaceutical Information - LIVOSTIN NASAL SPRAY". Retrieved 13 November 2005. 
Decongestants and other nasal preparations (R01)
Topical
Antiallergic agents,
excluding corticosteroids
Other nasal preparations
Systemic use:
Sympathomimetics

M: RES

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fr:Lévocabastine
  1. ↑ Pipkorn U, Bende M, Hedner J, Hedner T., A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis. Allergy. 1985 Oct;40(7):491-6.
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