Adrenorphin

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Adrenorphin
File:Adrenorphin.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 88377-68-8
PubChem 122176
ChemSpider 108968
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C44H69N15O9S
Molar mass 984.18 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Adrenorphin, also sometimes referred to as metorpham​ide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) that is produced from proteolyic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain.[1][2][3][4][5] It was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well.[1] Adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist, while having no effects on δ-opioid receptors.[2] It has analgesic and respiratory depressant effects.[6]

See also

References

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  1. 1.0 1.1 Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature. 305 (5936): 721–3. PMID 6633641. 
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