Ciladopa

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Ciladopa
File:Ciladopa.png
Systematic (IUPAC) name
2-{4-[(2S)-2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]piperazin-1-yl}cyclohepta-2,4,6-trien-1-one
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 80109-27-9
ATC code none
PubChem CID 133371
ChemSpider 117659
Chemical data
Formula C21H26N2O4
Molar mass 370.44 g/mol[[Script error: No such module "String".]]
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Ciladopa (AY-27,110) is a dopamine agonist with a similar chemical structure to dopamine.[1] It was under investigation as an antiparkinsonian agent but was discontinued due to concerns of tumorogenesis in rodents.[2][3][4][5]

References

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  1. Voith K (1985). "The comparative long-term effects of ciladopa (AY-27,110), a chemically novel dopaminergic agonist, in 6-OHDA-lesioned and intact rats". Psychopharmacology. 85 (4): 405–9. PMID 3927334. 
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  3. Weiner WJ, Factor SA, Sanchez-Ramos J, Berger J (1987). "A double-blind evaluation of ciladopa in Parkinson's disease". Movement Disorders : Official Journal of the Movement Disorder Society. 2 (3): 211–7. doi:10.1002/mds.870020308. PMID 3332914. 
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