Pronethalol

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Pronethalol
File:Pronethalol.svg
Systematic (IUPAC) name
1-(naphthalen-2-yl)-2-(propan-2-ylamino)ethanol
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 51-02-5
ATC code none
PubChem CID 4930
ChemSpider 4761
Chemical data
Formula C15H19NO
Molar mass 229.32 g/mol[[Script error: No such module "String".]]
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Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.[1]

See also

References

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  1. Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J. 24 (4): 336–42. PMC 325477Freely accessible. PMID 9456487.