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File:6-APB structure.png
Systematic (IUPAC) name
Clinical data
  •  ?
Legal status
Legal status
  • Uncontrolled
CAS Number 286834-85-3
286834-84-2 (hydrochloride)
ATC code none
PubChem CID 9794343
ChemSpider 7970110
Chemical data
Formula C11H13NO
Molar mass 175.23 g/mol[[Script error: No such module "String".]]
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6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB) is a stimulant and entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. There is currently no toxicology data availble and there is no history of human use.


6-APB has not been properly assayed in terms of pharmacological action, but based on its effects and chemical similarity to other amphetamines, it likely acts as a releasing agent of serotonin, norepinephrine, and dopamine.[citation needed] Though its effects on monoamine release have not been validated, 6-APB has been shown to act as an agonist of the 5-HT2C receptor.[1] It may also act as an agonist of the 5-HT2A and 5-HT2B receptors, the former likely explaining its psychedelic effects.

Upon overdose 6-APB has been widely reported to cause serotonin syndrome.


6-APB is unscheduled in the United States. However, this chemical may be covered under the Federal Analogue Act in the United States.

Certain countries contain a "substantially similar" catch all clause in their drug law, such as New Zealand and Australia. This includes 6-APB as it is in some respects similar in chemical structure to the class A drug MDA, meaning 6-APB is likely to be viewed as a controlled substance analogue in these jurisdictions.[2]

Canada - Controlled under item 1 of Schedule III of the CDSA.

See also


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  1. US patent 7045545, Karin Briner et al, "Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists", published 2000-01-19, issued 2006-16-03 
  2. "Misuse of Drugs Act 1975 New Zealand". legislation.govt.nz. Retrieved 2010-08-06.  Text "Accessed 23:50 GMT 6 August 2010 " ignored (help)