|style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers|
|SMILES||Script error: No such module "collapsible list".|
|InChI||Script error: No such module "collapsible list".|
|style="background: #F8EABA; text-align: center;" colspan="2" | Properties|
|Molar mass||241.35 g/mol|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)|
2C-T-2, or 2,5-dimethoxy-4-ethylthiophenethylamine is a psychedelic and entheogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin. The drug has structural and pharmacodynamic properties similar to the drug 2C-T-7.
In Alexander Shulgin's book PiHKAL (Phenethylamines i Have Known And Loved), the dosage range is listed as 12 to 25 mg. According to Erowid a threshold dose would be 5 mg, a light dose would range from 8–15 mg, a common dose is 15–22 mg and a strong dose would be considered to be 20–40 mg.
Effects are similar to the related 2C-T-7, but 2C-T-2 is said to produce more of a "body-load" and other unpleasant reactions with reported reddening of the face and warm flushes. It can also be very nauseating while coming up, some users report a period of restlessness during the come up and feeling cold, this can become quite unpleasant. There have been no reported deaths from 2C-T-2, unlike 2C-T-7, and the psychedelic effects have been much milder. The onset usually starts after about an hour of ingestion and rises for about 2 hours, then the user hits the plateau. Hallucinations similar to those created by LSD and other serotonergic hallucinogens are very prominent on typical 2C-T-2 doses. The trip is often described as being similar to LSD due to the serotonergic effects and hallucinations, and has some aspects similar to other phenethylamines like MDMA (users sometimes have euphoric rushes); however, unlike MDMA, 2C-T-2 is a strong psychedelic, and its effects can be unpredictable, even for experienced users. 2C-T-2 can be just as powerful as LSD, LSA and other hallucinogens. Because of the particular body load of this substance, there is a larger potential for experiencing a bad trip as compared to similar hallucinogens. There are no known reports of neurotoxicity currently, as 2C-T-2 is a research chemical. However, it is commonly assumed that it would have the same safety level of 2C-B (since research has been done on it). Effects can last up to 16 hours from dosing.
The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
The toxicity of 2C-T-2 is not well documented. 2C-T-2 is considerably less potent than 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when combined with stimulant drugs. Most confirmed fatalities involving 2C-T drugs involve their combination with other drugs such as alcohol, MDMA (ecstasy) or cocaine. It is also dangerous for a person who takes certain kinds of medication, OTC or prescription, to ingest 2C-T-2. Unfortunately not much is known about contraindications.
The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium Law.
2C-T-2 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-2 with evidence of intent for human consumption would probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7.
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- PiHKAL #40 2C-T-2
- 2C-T-2 entry in PiHKAL • info
- 2C-T-2 vault at Erowid
- Sulfurous Samadhi: An Investigation of 2C-T-2 & 2C-T-7
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- Last Argentina Controlled Drugs List