RTI-31

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RTI-31
File:Chlorophenyltropane.png
Systematic (IUPAC) name
methyl (1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Identifiers
CAS Number 130342-80-2
PubChem CID 131195
Chemical data
Formula C16H20ClNO2
Molar mass 293.12 g/mol[[Script error: No such module "String".]]
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(–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-31) is a synthetic analog of cocaine that acts as a stimulant.[1] Semi-synthesis of this compound is dependent upon the availability of cocaine starting material.

Further chemical modification of RTI-31 leads to novel chemical entities; some of them are highly potent, and one of them has been reported as lasting for three days.[2]

RTI-31 is also used in the synthesis of other compounds such as RTI-113 and RTI-336.

References

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See also

  1. Wee, S.; Carroll, F.; Woolverton, W. (2006). "A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 31 (2): 351–362. doi:10.1038/sj.npp.1300795. PMID 15957006.  More than one of |author2= and |last2= specified (help); More than one of |author3= and |last3= specified (help) edit
  2. Kozikowski, AP; Eddine Saiah, MK; Johnson, KM; Bergmann, JS (1995). "Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position". Journal of Medicinal Chemistry. 38 (16): 3086–93. doi:10.1021/jm00016a012. PMID 7636872.  edit