Bupranolol
File:Bupranolol.svg | |
Systematic (IUPAC) name | |
---|---|
(RS)-1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol | |
Clinical data | |
Routes of administration | Oral, topical (eye drops) |
Pharmacokinetic data | |
Bioavailability | < 10% |
Protein binding | 76% |
Metabolism | First pass elimination > 90% |
Biological half-life | 2-4 hours (plasma) |
Excretion | > 88% renal (as carboxybupranolol) |
Identifiers | |
CAS Number | 23284-25-5 |
ATC code | C07AA19 (WHO) |
PubChem | CID 2475 |
IUPHAR/BPS | 550 |
Chemical data | |
Formula | C14H22ClNO2 |
Molar mass | 271.78298 g/mol[[Script error: No such module "String".]] |
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Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol.
Contents
Uses and dosage
Like other beta blockers, oral bupranolol can be used to treat hypertension and tachycardia. The initial dose is 50 mg two times a day. It can be increased to 100 mg four times a day. Bupranolol eye drops (0,05%-0,5%) are used against glaucoma.
Pharmacology
Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid, of which 88% are eliminated renally within 24 hours.
Adverse effects, contraindications, interactions
Adverse effects, contraindications and interactions are similar to other beta blockers.
References
Dinnendahl, V, Fricke, U, ed. (2007). Arzneistoff-Profile (in German). 2 (21 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-98-46-3.
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