ICI-118,551
| ICI-118,551 | |
|---|---|
| File:ICI 118551.svg | |
| 3-(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 72795-19-8 |
| PubChem | 3682 |
| MeSH | ICI+118551 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C17H27NO2 |
| Molar mass | 277.402 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
ICI-118,551 is a selective beta-2 (β2) adrenergic receptor antagonist.[1][2] ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor.[3][4] The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008.
ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known.[5] When dissolved in saline, the compound crosses the blood-brain barrier. Common systemic doses used in rodent research are .5 or 1 mg/kg although efficacy has been demonstrated at doses as low as .0001 mg/kg in rhesus monkeys.[6] Doses up to 20 mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to at least 2.5 mg/mL.
References
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- ↑ Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). "A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors". Journal of Pharmacological and Toxicological Methods. 58 (3): 189–97. doi:10.1016/j.vascn.2008.06.003. PMID 18652905.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Ruffolo, Robert R. Jr. ed. 1995. Adrenoceptors: Structure, Function. and Pharmacology. Harwood Academic Publisher, Luxembourg.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
