Ajmalicine

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Ajmalicine
File:Ajmalicine.png
Systematic (IUPAC) name
(19α)-16,17-didehydro- 19-methyloxayohimban- 16-carboxylic acid methyl ester
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
CAS Number 483-04-5
ATC code none
PubChem CID 251561
ChemSpider 220386
Chemical data
Formula C21H24N2O3
Molar mass 352.43 g/mol[[Script error: No such module "String".]]
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Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.[1] It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, and Sarpan.[1] It is also an alkaloid found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa.[1][2][3]

Ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. Like corynanthine, it acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects.[1][4]

See also

References

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Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
Adrenergic release inhibitors
Peripheral
Indirect
Direct
Non-selective α blocker
Other antagonists
dual (Bosentan) • selective (Ambrisentan, Sitaxentan)


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fr:Ajmalicine
  1. ↑ 1.0 1.1 1.2 1.3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3. 
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