NAN-190

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NAN-190
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Systematic (IUPAC) name
1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
Identifiers
CAS Number 115388-32-4
PubChem CID 4431
IUPHAR/BPS 73
Chemical data
Formula C23H27N3O3
Molar mass 393.478 g/mol[[Script error: No such module "String".]]
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NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor.[1] The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin receptor antagonist.[1]

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References

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  1. ↑ 1.0 1.1 Foong JP, Bornstein JC. (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig". Neuroreport. 20 (3): 325–330. doi:10.1097/WNR.0b013e3283232caa. PMID 19190523. 
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