Search results

| metabolism = [[Liver|Hepatic]] ([[CYP2E1]]<ref>[http://redpoll.pharmacy.ualberta.ca/dr ...ly, halothane is not an [[ether]]. Attempts to find anaesthetics with less metabolism led to [[halogenated ethers]] such as [[enflurane]] and [[isoflurane]]. The

| metabolism = liver; CYP450

| metabolism = [[Liver|Hepatic]] (mostly [[CYP3A4]] and [[CYP2C19]]-mediated)

| metabolism = Extensively hepatic; main metabolite is inactive

| metabolism = [[Liver|Hepatic]] [[hydroxylation]] ([[CYP2C9]]-mediated)

| metabolism =

| metabolism = [[hepatic]]

| metabolism = [[Liver|Hepatic]], 90% [[CYP1A2]]-mediated

| metabolism = hepatic (80% oxypurinol, 10% allopurinol ribosides) ...resulting in the production of [[uric acid]], the product of human purine metabolism.<ref name="pmid16507884"/> In addition to blocking uric acid production, in

| metabolism = Liver ...s, which the parasite requires to construct its own protein and for energy metabolism. Digestion is carried out in a vacuole of the parasite cell.

| metabolism = [[Liver|Hepatic]] ([[CYP2D6]])

| metabolism = [[hepatic]]

| metabolism =

| metabolism = [[hepatic]] ...ism is through scavenging of [[acetaldehyde]], a toxic intermediate in the metabolism of ethanol.<ref>Fawkes, SW [http://www.ceri.com/alcohol.htm CERI: Living wi

| metabolism = ?

| bioavailability = 2% (Oral, 90% absorption but high [[first-pass metabolism]]) | metabolism = [[Liver]]

| metabolism = Hepatic * In [[Wilson's disease]], a rare genetic disorder of [[copper]] metabolism, penicillamine treatment relies on its binding to accumulated copper and el

| metabolism = [[Liver|Hepatic]]—by [[CYP3A4]], to active [[epoxide]] form (carbamazep ...channel blocker]]s.<ref name=Lexi-Comp/> Carbamazepine also increases the metabolism of the hormones in [[birth control pill]]s and can reduce their effectivene

| metabolism = [[Liver|Hepatic]] (mostly [[CYP2C19]]) Phenobarbital was used to treat [[neonatal jaundice]] by increasing liver metabolism and thus lowering [[bilirubin]] levels. In the 1950s, [[phototherapy]] was

| metabolism = [[hepatic]]

| metabolism = oxidation of sulfur atom to [[sulfoxide]], the active metabolite

| metabolism = [[Liver|Hepatic]]

| metabolism = Hepatic

...8 | Cl=2 | N=2 | O=4| molecular_weight = 327.119 g/mol| bioavailability= | metabolism = | elimination_half-life=| excretion = | pregnancy_category = | legal_sta

| metabolism = hepatic ...als#Imidazole_and_triazole_antifungals|azole]] antifungals will affect the metabolism of praziquantel.

|metabolism = [[Liver|Hepatic]]

| metabolism = [[Liver|Hepatic]] Chloramphenicol increases the absorption of [[Human iron metabolism|iron]].<ref>{{cite encyclopedia |encyclopedia= Pill Book, The |title= Iron

| metabolism = hepatic,minimally

| metabolism = liver (under 5% excreted unchanged) === Metabolism ===

| metabolism = ...ndoval R, Molitoris BA: Gentamicin Inhibits Renal Protein and Phospholipid Metabolism in Rats: Implications Involving Intracellular Trafficking. J Am Soc Nephrol

| metabolism = [[Hepatic]] ...ents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines |journal=International Journal of Toxicology |volume=2

| metabolism = liver (75%) ...phys Acta | volume=402 | pages=142&ndash;49 }}</ref> respiration, pyruvate metabolism and other macromolecules within the cell. It is not known which of the act

|metabolism = [[hepatic]]

| metabolism = ?

| metabolism = Excreted unchanged

| metabolism = ==Metabolism==

| metabolism = [[Liver|Hepatic]] (mostly [[CYP2E1]]-mediated)

|metabolism = [[Liver|Hepatic]] and intestinal wall ...P450]] enzymes (such as [[CYP2C9]] and [[CYP3A4]]), increasing the rate of metabolism of many other drugs that are cleared by the liver through these enzymes. As

| metabolism = [[Liver]]

| metabolism = liver; CYP450: 2C19, 3A4 inhibitor ==Metabolism==

| metabolism = [[Liver|Hepatic]]

| metabolism =

| metabolism =

| metabolism =

| metabolism = Hepatic

...bioavailability = | protein_bound = Approximately 30% bound to proteins. | metabolism = | elimination_half-life = 2 to 3 hours | pregnancy_category = | legal_sta

| metabolism = Unknown

| metabolism = [[hepatic]] ...-demethylase|cytochrome P450 oxidase]] and may alter the [[drug metabolism|metabolism]] of other drugs.

| metabolism = Hepatic 11% ...azole follows zero order kinetics, and only 10% of elimination is due to [[metabolism]], the remainder is excreted in urine and sweat. Patients with impaired ren

| metabolism = [[Liver|Hepatic]] [[demethylation]] and [[glucuronidation]]

| metabolism = ?

| metabolism = renal ...b. "Amphotericin B and Its New Derivatives - Mode of Action." Current Drug Metabolism. 10.5 (2009): 459-69. Print.</ref> The actual mechanism of action may be mo

| metabolism = Minimal, in the [[Gastrointestinal tract|GI tract]]

| metabolism = Viral thymidine kinase ...tion of further activity of DNA polymerase. Acyclo-GTP is fairly rapidly [[metabolism|metabolised]] within the cell, possibly by cellular [[phosphatase]]s.

|metabolism=[[Liver|Hepatic]]

| metabolism =

| metabolism = [[Liver|Hepatic]] [[oxidation]] and [[glucuronidation]]<br>[[Cytochrome P

| metabolism =

| metabolism = Renal elimination (ca.40%)

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP3A4]] and [[CYP2B6]]-mediated) ...nthard HF, Bleiber G, Krause M. Efavirenz intoxication due to slow hepatic metabolism. ''Clinical Infectious Diseases''. 2005 Feb 1;40(3):e22-3. PMID 15668854</r

|metabolism = [[Liver|Hepatic]]

| metabolism = [[Liver|Hepatic]] via [[CYP3A4]]

| metabolism = [[Liver|Hepatic]]

| metabolism = * [[amiodarone]] - decreased metabolism, possible toxicity

| metabolism =

| metabolism = Hepatic metabolism by CYP450 incl. CYP3A4

| metabolism = Metabolized to 5'phosphates, de-riboside, and deriboside carboxylic acid ...es [[purine]] [[RNA]] [[nucleotide]]s. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is

| metabolism = [[hydrolysis|Hydrolyzed]] to furoic acid and diloxanide, which und

| metabolism = [[Liver|Hepatic]], via [[CYP2D6]] (Cytochrome P450 2D6)<ref>{{Cite journa ...gth ranges from 8 to 12 percent of morphine in most people; differences in metabolism can change this figure as can other medications, depending on its route of

...of [[nitric oxide]]'s importance to human metabolism and human endogenous metabolism of nitrite.

| metabolism = 50% [[hydrolyse]]d to [[tropine]] and [[tropic acid]]

| metabolism = [[Liver|Hepatic]]

...rms to N-demethylation of ketamine in human liver microsomes |journal=Drug Metabolism and Disposition |volume=30 |issue=7 |pages=853–8 |year=2002 |month=July | ...s those in humans to start with. It is because of this higher base rate of metabolism that ketamine causes over-excitement in rats at doses below those at which

| metabolism = Hepatic, including [[CYP1A2]] ...floxacin being an inhibitor of human cytochrome P450 1A2 (CYP1A2) mediated metabolism. The new warning stated: <blockquote>"Coadministration of ciprofloxacin wit

| metabolism = ==Metabolism==

| metabolism = [[Hepatic]] == Metabolism ==

| metabolism = None Metformin is not [[drug metabolism|metabolized]]. It is [[clearance (medicine)|cleared]] from the body by [[re

| metabolism = [[Liver|Hepatic]]—[[glucuronidation|glucuronide conjugation]] 30–50%, ...Graw-Hill]] |location=New York |isbn=978-0071422802|pages=79 |chapter=Drug Metabolism }}</ref> By inhibiting mEH, valproic acid causes a buildup of the active me

| metabolism = Hepatic ...fluoxetine_cp.htm | title = Prozac Pharmacology, Pharmacokinetics,Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref>

| bioavailability = 88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability | metabolism = [[Liver|Hepatic]] [[glucuronidation]] and [[sulfoxide|sulfoxidation]]

...s control systems as the gas is undetectable to the human senses, toxic to metabolism and neurotoxic.

| metabolism = [[Liver|Hepatic]] As much as 80% of therapeutic doses of salicylic acid is [[metabolism|metabolized]] in the [[liver]]. Conjugation with [[glycine]] forms [[salicy

| Metabolism =

| metabolism =

| metabolism = oxidation to the sulfone and sulfoxide parent compound

| metabolism = 12 to 50%

| metabolism = ?

| metabolism =

| metabolism =

| metabolism = [[hepatic]]

| metabolism = [[Liver|Hepatic]] ([[CYP2C19]], [[CYP3A4]]) ...nteraction|interact]] with drugs that depend on them for [[drug metabolism|metabolism]], such as [[diazepam]], [[escitalopram]], and [[warfarin]]; the concentrat

| metabolism = [[Liver|Hepatic]] ===Drug metabolism and excretion===

| metabolism = [[Liver|Hepatic]] <10%

| metabolism = hepatic (to enalaprilat)

| metabolism = Hepatic

...urnal |author=Beermann B, Groschinsky-Grind M, Rosén A.|title=Absorption, metabolism, and excretion of hydrochlorothiazide |journal=Clin Pharmacol Ther |volume=

| metabolism = [[Liver|Hepatic]]

| Metabolism = Circulatory ==Metabolism and toxicity==

| metabolism = [[Liver|Hepatic]] (16%)

| metabolism = hepatic and renal [[glucuronidation]]

| metabolism = [[Hepatic]] ([[CYP3A4]])

| metabolism = [[Liver|Hepatic]]: 80%

| metabolism = None

| metabolism = not metabolized

...of all forms of life. When bound to [[coenzyme A]], it is central to the [[metabolism]] of [[carbohydrate]]s and [[fat]]s. However, the concentration of free ace

| metabolism =

| metabolism = [[Liver|Hepatic]] ...ilure patients with diastolic dysfunction have evidence of active collagen metabolism and increasing fibrosis {{Citation needed|date=January 2010}}).

| metabolism =

| metabolism = By [[xanthine oxidase]] [[Image:AZA metabolism.jpg|right|thumb|350px|Metabolic pathway for azathioprine]]

==Biological metabolism==

|metabolism = [[Liver|Hepatic]]

[[File:Glucose metabolism.svg|thumb|250px|Glucose metabolism and various forms of it in the process. Glucose is critical in the production of [[protein]]s and in [[lipid]] metabolism. In plants and most animals, it is also a [[precursor (chemistry)|precursor

| metabolism =

| metabolism = [[Liver|Hepatic]] ...Laghi F |title=Effects of oral albuterol on serum lipids and carbohydrate metabolism in healthy men |journal=Metab. Clin. Exp. |volume=45 |issue=6 |pages=712–

| metabolism = [[Hepatic]]

| metabolism = none

| metabolism = [[Hepatic]]

| metabolism = ...sis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism.<ref>First Aid USMLE Step 1 2009, Tao Le et al.</ref> It also decreases bon

| metabolism = Hepatic ([[CYP2C9]]) ...r]]s of ibuprofen, with the potential for different biological effects and metabolism for each enantiomer.

|metabolism = [[synapse|adrenergic synapse]] ([[Monoamine oxidase|MAO]] and [[Catechol-

| Metabolism = 0.004%

| bioavailability = near complete absoprtion, following first-pass metabolism systemic availability 65% (range 52 to 75%) | metabolism = [[Liver|Hepatic]]

| metabolism = [[Hepatic]] 90% ...ory self-limiting in length and overall impact in that a rapid increase in metabolism and other bodily processes takes place, including shedding and replacement

| metabolism = 90 to 95% [[Liver|Hepatic]] ...entury, until two teams of researchers from the United States analyzed the metabolism of acetanilide and paracetamol.<ref name=drugdiscov/> In 1947 [[David Leste

| metabolism = minimal [[hepatic]]

| metabolism = [[Liver|Hepatic]] - [[CYP2C19]] ...rnal |author=Mandrioli, R., L. Mercolini, M.A. Raggi |title=Benzodiazepine metabolism: an analytical perspective |journal=Curr. Drug Metab. |volume=9 |issue=8 |p

| metabolism = less than 30% biotransformed in [[liver]]

| metabolism = [[hepatic]]

...plants growing in arid regions photosynthesize through [[Crassulacean acid metabolism]].

|metabolism=[[Liver|Hepatic]] ...mazepam was well absorbed and found to have minimal (8%) first pass [[drug metabolism]]. There were no active metabolites formed and the only significant metabol

...Chemicals&nbsp;and&nbsp;the&nbsp;Vital&nbsp;Processes]] '''3.2.2'''&nbsp;[[Metabolism]]:&nbsp;[[Bioenergetics]]&nbsp;and&nbsp;[[Biosynthesis]] '''3.2.3'''&nbsp;[

...e same sun-baked boulder happens to host a ground squirrel, the animal's [[metabolism]] will adjust to the lesser need for internal heat production. *[[Metabolism]]

|metabolism = Not metabolised

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = Hepatic and via erythrocytes

| metabolism =

| metabolism =

| metabolism =

| metabolism = ...e? Precursor compounds to amphetamine and methamphetamine | journal = Drug Metabolism Reviews | volume = 32 | issue = 1 | pages = 15–44 | year = 2000 | month =

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP2D6]]-mediated)

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = ...ite journal |author=Wink, M. |title=Quinolizidine Alkaloids: Biochemistry, Metabolism, and Function in Plants and Cell Suspension Cultures. |journal=Plant Medica

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = glucuronidation (primary) Tocaine is a [[lidocaine]] analog, that does not have significant 1st pass metabolism. It is found in two [[enantiomer]]s. The R isomer is 4x as potent as the

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = None ...|hydrophilic]], has long [[half-life]] and tissue penetration and is not [[metabolism|metabolized]] by the liver.

| metabolism = converted to spiraprilat

| metabolism =

...patrilat after oral administration to rats, dogs, and humans |journal=Drug Metabolism and Disposition: the Biological Fate of Chemicals |volume=34 |issue=6 |page

| metabolism =

| metabolism =

| Metabolism =

| metabolism =

| metabolism =

| metabolism =

...I, Vagabov V, Kulakovskaya T |title=New aspects of inorganic polyphosphate metabolism and function |journal=J. Biosci. Bioeng. |volume=88 |issue=2 |pages=111–2

| metabolism =

| Metabolism =

| Metabolism =

...which is active in the respiratory chain. Oxygen has a special role in the metabolism of aerobic organisms. In many cases oxygen is directly incorporated into th

| metabolism =

| Metabolism =

...] or otherwise break these glycosidic bonds before such compounds become [[metabolism|metabolised]]. After digestion and absorption. the principal monosaccharide

| Metabolism =

{{Main|Human iron metabolism}} ...0079|title=How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism|year=2003|last=Rouault | first = Tracey A.|journal=PLoS Biology|volume=1|pa

| Metabolism =

...name=Ullmann/> Allergic reactions to PABA can occur. PABA is formed in the metabolism of certain ester local anesthetics, and many allergic reactions to local an

| metabolism =

| Metabolism =

| metabolism =

|metabolism = | title = Metabolism of phenazopyridine by isolated rat hepatocytes

| metabolism = [[Liver|Hepatic]] [[acetylation]] and [[glucuronidation]]

| metabolism =

| metabolism =

| metabolism = Rapidly & extensively metabolised intestinal mucosal wall and the liver ...that traps [[free radicals]], which are potentially damaging byproducts of metabolism.{{Citation needed|date=January 2010}}

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP3A4]], [[CYP1A2|1A2]] and [[CYP2C8|2C8]]-m

| metabolism =

| metabolism =

| metabolism =

| metabolism = [[Hydrolysis]] by plasma esterases

| metabolism =

...1=Docampo | first1=R. | last2=Moreno | first2=S.N. | year=1990 | title=The metabolism and mode of action of gentian violet | journal= Drug Metab. Rev. | volume=2

Aquatic animals [[metabolism|metabolize]] malachite green to its leuco form. Being non-polar, LMG is ret ...| doi = 10.1139/cjfas-53-6-1427 | title = Uptake, tissue distribution, and metabolism of malachite green in the channel catfish (''Ictalurus punctatus'')}}

| metabolism =

| metabolism =

| metabolism =

| metabolism = liver primarily

| metabolism =

| metabolism = near complete hepatic metabolism to inactive metabolites

| metabolism =

| metabolism =

| metabolism = Hepatic <ref name="kinetics2" /> ...side effects becomes greater when taken with other drugs that inhibit its metabolism.

| metabolism =

| metabolism =

| metabolism = ...es a venom cocktail injected into the brain to manipulate the behavior and metabolism of its cockroach prey|journal=Archives of Insect Biochemistry and Physiolog

| metabolism = *Increases [[metabolism]]

| metabolism = [[Liver|Hepatic]] ([[monoamine oxidase]]) Oral phenylephrine is extensively [[metabolism|metabolised]] by [[monoamine oxidase]] <ref>[http://www.pharmgkb.org/do/ser

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

'''Imidazol-4-one-5-propionic acid''' is an intermediate in the metabolism of [[histidine]]. {{Amino acid metabolism intermediates}}

| metabolism =

==Metabolism and sources== ...ref name=Mann>{{cite journal |author=Mann T, Leone E |title=Studies on the metabolism of semen. VIII. Ergothioneine as a normal constituent of boar seminal pla

| Metabolism =

...sm of dihalomethanes to carbon monoxide. II. In vitro studies|journal=Drug metabolism and disposition|year=1975|pages=104–112|volume=3|issue=2|pmid=236156|mont ...oxidase is slow, causing a relatively prolonged impairment of [[oxidative metabolism]].<ref name="JToxClinTox1994-hardy"/>

...> This can be accomplished by avoiding [[carcinogen]]s or altering their [[metabolism]], pursuing a lifestyle or diet that modifies cancer-causing factors and/or

Even if it is not a common substrate for the metabolism of organisms, benzene could be oxidized by both [[bacteria]] and [[eukaryot ...al=Mutat Res|issue=1|volume=322| pages=9–20|pmid=7517507}}</ref> Benzene metabolism involves enzymes coded for by polymorphic genes. Studies have shown that ge

...ite journal|last=Nicholis|first=I.|year=2009|title=Arsenite medicinal use, metabolism, pharmacokinetics and monitoring in human hair| journal=Biochimie| pmid=195

...omium (Cr(III)) is required in trace amounts for [[sugar]] and [[lipid]] [[metabolism]], few cases have been reported where its complete removal from the diet ha Chromium is has been suggested to be connected to sugar metabolism, although no biological role for chromium has ever been demonstrated bioche

...cyte]]s.<ref name="Casarett07-946"/> Lead also interferes with the normal metabolism of [[calcium in biology|calcium in cells]] and causes it to build up within ...f lead from the mother's bones is subsequently mobilized by the changes in metabolism due to pregnancy; increased calcium intake in pregnancy may help mitigate t

| metabolism = [[Glucuronidation]]

| metabolism = [[Liver|Hepatic]] [[glucuronidation]]

| Metabolism =

| Metabolism =

...in medicine to treat disorders associated with bone formation and calcium metabolism. Furthermore they serve as carriers for radionuclides in bone cancer treat

[[Category:Metabolism]]

| metabolism = Nil

...an intermediate in the [[citric acid cycle]] and therefore occurs in the [[metabolism]] of virtually all [[Life|living things]]. It can also be used as an enviro

...|'''A'''bsorption]], [[Distribution (pharmacology)|'''D'''istribution]], [[metabolism|'''M'''etabolism]], and [[excretion|'''E'''xcretion]]) of the drug. Hence

...process in plants and animals, the most significant example being [[energy metabolism]] and storage. All living cells require a continual supply of energy for tw

...ion from the tubular epithelial cells, and lowering rates of [[glutamine]] metabolism and ammonia excretion.

#Production of [[nonvolatile acid]]s from the metabolism of proteins and other [[organic molecule]]s #Use of hydrogen ions in the metabolism of various organic anions

...n-oxygen-carrying function as an [[antioxidant]] and a regulator of [[iron metabolism]].<ref name="Biagioli">Biagioli M, Pinto M, Cesselli D, Zaninello M, Lazare ...val from the body after the oxygen has been released to tissues undergoing metabolism. This increased affinity for carbon dioxide by the venous blood is known as

...ed to [[glucose]]; one [[gram]] of GDL yields roughly the same amount of [[metabolism|metabolic]] energy as one gram of [[sugar]].

- [[Metabolism]]

== Resulting from errors in metabolism == {{see also|Category:Skin conditions resulting from errors in metabolism}}

* [[Mental retardation X linked borderline Maoa metabolism anomaly]]

* [[Inborn amino acid metabolism disorder]] * [[Inborn error of metabolism]]

...nd hyperextension of the legs. It is caused by a disorder in [[serotonin]] metabolism that causes a deficiency of available serotonin.<ref name=Ettinger_1995/>

..., giving victims increased strength, speed and agility but also a faster [[metabolism]]. This results in increased [[body temperature]], [[heart rate]], and brea |The metabolism of victims are increased and the surface of their skin hardens and forms a

...giogenesis plays an important [[physiological]] role in [[homeostasis]], [[metabolism]] and [[immunity (medical)|immunity]]. Lymphatic vessel formation has also

...bsorption from the small intestine, the lymphatic system avoids first pass metabolism.

...and [[RNA]] and an essential element for all [[living cell]]s. Phosphate [[metabolism]] is the complete set of [[Phosphate reaction|phosphate chemical reaction]] ==Phosphate metabolism==

...[Shock (circulatory)|hemorrhagic shock]] while also recycling [[Human iron metabolism|iron]].<ref name="Mebius">Mebius RE, Kraal G. (2005). Structure and functio

...well as depletion of -SH groups of glutathione which are essential for the metabolism of the drugs to their active forms.

...ssed January 4, 2007.</ref> CBF is tightly regulated to meet the brain's [[metabolism|metabolic]] demands.<ref name="Orlando Regional Healthcare"/><ref name="sgo

'''Training effect''' is the elevation of [[metabolism]] through physical exercise. This effect was discovered by [[Kenneth H. Coo

...atch of blood supply (oxygen/fuel delivery) and blood request for adequate metabolism of tissue. Ischemia results in tissue damage because of a lack of [[oxygen]

...pmid=19289474 |doi=10.1136/jnnp.2008.168179 |url=}}</ref> and [[Human iron metabolism|iron]] deposits around the cerebral veins.<ref name="pmid19724286">{{Cite j

...network of capillaries supplying an [[organ (biology)|organ]]. The more [[Metabolism|metabolically]] active the cells, the more capillaries they will require to

...MA) is a naturally occurring chemical found in [[blood plasma]]. It is a [[metabolism|metabolic]] [[by-product]] of continual [[protein]] modification processes ...om the [[methyl]] group donor S-adenosylmethionine, an intermediate in the metabolism of [[homocysteine]]. (Homocysteine is an important blood chemical, because

| metabolism =

...ermediate between other types of muscle in terms of appearance, structure, metabolism, excitation-coupling and mechanism of contraction. Cardiac muscle shares si ==Metabolism==

In addition to metabolism, the coronary circulation possesses unique pharmacologic characteristics. P

| metabolism = ?

| metabolism =

| metabolism = [[Hepatic]] ==Metabolism==

| metabolism = [[Liver|Hepatic]]

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP3A4]] and [[CYP2C9|2C9]] involved)

| metabolism =

| metabolism =

...tle=ScienceDirect - Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism : Bioactive long chain N-acylethanolamines in five species of edible bivalv

| metabolism =

| metabolism = Not appreciably metabolized

...anoic acid as the end product of their [[anaerobic respiration|anaerobic]] metabolism. This class of bacteria is commonly found in the stomachs of [[ruminant]]s ==Metabolism==

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| Metabolism =

| metabolism =

| metabolism = ...the rate of THC clearance from the body, perhaps by interfering with the [[metabolism]] of THC in the [[liver]].

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = ==Metabolism==

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = Variable

| metabolism =

| metabolism =

| metabolism = ...;46(9):799-804. doi: 10.1002/jlcr.720</ref>. No public data about AM-694 [[metabolism]] is known.

| metabolism =

| metabolism =

| metabolism =

| metabolism = mostly hepatic by CYP2C<ref name="pmid12648025"/> ==Metabolism==

| Metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism =

...X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism |journal=J. Biol. Chem. |volume=278 |issue=49 |pages=49448–58 |publisher=

...m in induced comas is to reduce the [[intracranial pressure]], not brain [[metabolism]]).

...ume=269|issue=26|pages=17359–17362|pmid=8021233}}</ref> alterations in [[metabolism]],<ref name=rosen>{{cite journal|author =Rosen O|title=After insulin binds| ...uch as control of cell growth, [[cell differentiation|differentiation]], [[metabolism]], and [[cell migration|migration]].<ref name=LiHris/>

| metabolism = [[hepatic]]

| metabolism = [[Liver|hepatic]]<br />[[CYP3A4]], [[CYP2C8]] ...ral solution. It is not administered orally, due to very high [[first-pass metabolism]].

| metabolism = Hepatic ...was not taking other longer-acting opioids, or have abnormalities in drug metabolism and/or liver or kidney function. All of the effects of hydromorphone and it

| metabolism = Hepatic ==Metabolism and excretion==

| metabolism = [[hepatic]], primarily by [[CYP3A4]] ...ite good absorbance from the small intestine there is extensive first-pass metabolism, leading to an oral bioavailability of 33%. Fentanyl lozenges are available

| metabolism = [[Hepatic]] ===Metabolism===

| metabolism =

| metabolism = PCP is retained in fatty tissue and is broken down by the human [[metabolism]] into [[PCHP]], [[4-Phenyl-4-(1-piperidinyl)cyclohexanol|PPC]] and [[PCAA]

| metabolism = Hepatic ...33220015fb97&keytype2=tf_ipsecsha |title=Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability

| metabolism = Hepatic (liver) enzymes: major [[CYP2D6]], minor [[CYP3A4]], and minor [[ ...Schmider J, Greenblatt DJ, Fogelman SM, von Moltke LL, Shader RI | title = Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4

| metabolism =

| metabolism =

| metabolism = [[Liver|Hepatic]]

| metabolism =

| metabolism = [[Liver|Hepatic]]

| metabolism = hepatic, no active metabolites exist

| metabolism = ?

| metabolism = [[Liver|Hepatic]] [[glucuronidation]]

| metabolism = 10% hepatic

| metabolism = [[Liver|Hepatic]] ([[CYP2C9]])

| metabolism =

| metabolism = To [[indometacin]]

| metabolism =

| metabolism =

| metabolism =

| metabolism =

|metabolism=

| metabolism =

| metabolism = [[Glucuronidation]]

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP2C9]] and [[CYP3A4|3A4]]-mediated)

| metabolism = liver

| metabolism =

| metabolism =

| metabolism = [[Liver]]—65% [[oxidation]] and 35% [[glucuronidation|glucuronic acid c

| metabolism =

| metabolism = [[Liver|Hepatic]] ([[CYP2C9]]) Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known

| metabolism = ...sciences and social sciences | pmc = 2844725}}</ref> Ketoprofen undergoes metabolism in the liver via conjugation with glucoronic acid, CYP3A4 and CYP2C9 hydrox

| metabolism =

| Metabolism =

| metabolism =

| metabolism =

| metabolism =

| metabolism = 4 to 10% [[kidney|renal]]

| metabolism =

| metabolism =

...in the [[urine]], although some drugs are partially excreted in [[bile]]. Metabolism may be abnormal in certain disease states, and accumulation may occur even

| metabolism =

| metabolism = [[Ester]] [[hydrolysis]] ...esia is induced for about 5–10 minutes even though the half-life of drug metabolism is approximately 75 minutes. This is because etomidate is redistributed fr

| metabolism = ...Toki S | title = [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehyd

| metabolism = [[Hepatic]] ...n.{{fact|date=November 2008}} Side-chain oxidation is the primary means of metabolism involvedtermination of the drug's biological activity.

| metabolism =

| metabolism =

| metabolism = [[Hepatic]]

| metabolism = [[Liver|Hepatic]] [[glucuronidation]]

==Metabolism== ...olism]].<ref>{{cite journal | title = Inhibition of N-Nitrosodimethylamine Metabolism in Rats by Ether Anesthesia | author = Larry K. Keefer, William A. Garland,

...loroform Extraction of Drugs and Metabolites with Amine Substituents",Drug Metabolism & Disposition November 1982 vol. 10 no. 6 561-567).

| metabolism = ...parative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selectivity toxicity in poikilotherms."''J Pharmacol Exp

| metabolism = 95%, mainly [[Hepatic]], also in blood and tissues ...was discovered that [[1,4-Butanediol|1,4-butanediol]] (1,4-B), which is [[metabolism|metabolized]] into GHB, had been substituted for the non-toxic plasticiser

...title = Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofront

...le to breastfeed:'' The child has a [[birth defect]] or [[inborn error of metabolism]] such as [[galactosemia]] that makes breastfeeding difficult or impossible ...ved in many different critical metabolic processes in the body like energy metabolism and enzymatic reactions. Also, as the building blocks of deoxyribonucleic a

* {{Cite journal|author=Manninen, A.H. |year=2002 |title=Protein metabolism in exercising humans with special reference to protein supplementation. Mas ...at Mass Loss in Overweight Police Officers |journal= Annals of Nutrition & Metabolism |year= 2000 |issue=44 |pages=21–29 |doi=10.1159/000012817 |author=Robert

...etary fat saturation effects on low-density-lipoprotein concentrations and metabolism in various animal models |journal=The American Journal of Clinical Nutritio

{{ATC codes lead|A||Alimentary tract and metabolism}}

| metabolism = [[Liver|Hepatic]]