Difference between revisions of "Xylazine"
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Latest revision as of 12:13, 20 September 2010
File:Xylazin.svg | |
Systematic (IUPAC) name | |
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N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine | |
Legal status | |
Legal status |
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Identifiers | |
CAS Number | 7361-61-7 |
ATCvet code | QN05CM92 (WHO) |
PubChem | CID 5707 |
IUPHAR/BPS | 523 |
Chemical data | |
Formula | C12H16N2S |
Molar mass | 220.33[[Script error: No such module "String".]] |
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Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Yohimbine (Yobine) and atipamezole (commercial name Antisedan) can be used to reverse xylazine effects. In veterinary anesthesia, xylazine is often used in combination with ketamine. No formal information in humans is available. Xylazine is sold by Bayer under the brand name Rompun.
Veterinary Indications
Veterinarians use xylazine as an emetic when it is desirable to remove a substance from a cat's stomach. In one trial, pilocarpine was used instead of xylazine.
References
- McCurnin, DM, and JM Bassert. Clinical Textbook for Veterinary Technicians, 5th ed. Saunders, Philadelphia, PA. 2002.
- Bayer Healthcare - Rompun Homepage http://www.rompun.com/. 2005.
- Wright, Dr. Bob. Human Health Concerns When Working With Medications Around Horses. Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA). http://www.omafra.gov.on.ca/english/livestock/horses/facts/00-063.html. 2005.
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