Fengabine

Fengabine
	File:Fengabine.png
Systematic (IUPAC) name
	(6Z)-6-[butylamino-(2-chlorophenyl)methylene]-4-chloro-cyclohexa-2,4-dien-1-one
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Identifiers
CAS Number	80018-06-0
ATC code	none
PubChem	CID 5362066
ChemSpider	4514924
Chemical data
Formula	C17H17Cl2NO
Molar mass	322.23 g/mol[[Script error: No such module "String".]]

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Fengabine (SL-79,229) is a drug which was investigated as an antidepressant but was never marketed.^[1]^[2] Its mechanism of action is unknown, but its antidepressant effects are reversed by GABA_A receptor antagonists like bicuculline and it has hence been labeled as GABAergic; however, it does not actually bind to GABA receptors, nor does it inhibit GABA-T.^[1]^[2] In clinical trials, fengabine's efficacy was comparable to that of the tricyclic antidepressants, but with a more rapid onset of action and much less side effects.^[3]^[4]^[5] Notably, fengabine lacks any sedative effects.^[4]

References

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↑ Magni G, Garreau M, Orofiamma B, Palminteri R (1989). "Fengabine, a new GABAmimetic agent in the treatment of depressive disorders: an overview of six double-blind studies versus tricyclics". Neuropsychobiology. 20 (3): 126–31. PMID 2668780.
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