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File:RS 67333.png
Systematic (IUPAC) name
CAS Number 160845-95-4
Chemical data
Formula C19H29N2O2Cl
Molar mass 352.9 g/mol
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RS-67,333 is an psychoactive drug and research chemical being investigated as a potential rapid-acting antidepressant,[1] nootropic,[2] and treatment for Alzheimer's disease.[3] It is a high-affinity 5-HT4 receptor partial agonist, as well as sigma receptor ligand with preference for the σ1 subtype.[4]


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  1. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). "Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action". Neuron. 55 (5): 712–25. doi:10.1016/j.neuron.2007.07.041. PMID 17785179. 
  2. Lamirault L, Simon H. (2001). "Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors". Neuropharmacology. 41 (7): 844–53. doi:10.1016/S0028-3908(01)00123-X. PMID 11684148. 
  3. Cho S, Hu Y. (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival". Experimental Neurology. 203 (1): 274–8. doi:10.1016/j.expneurol.2006.07.021. PMID 16978609. 
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