Lu AA21004

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Lu AA21004
Systematic (IUPAC) name
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Lu AA21004 is an antidepressant and anxiolytic currently under development by Lundbeck and Takeda for the treatment of major depressive disorder and generalized anxiety disorder.[1] It is a so-called "serotonin modulator and stimulator"[2] and acts as a serotonin transporter blocker (Ki = 5.4 nM), 5-HT1A receptor partial agonist (Ki = 15 nM; IA = 80%), and 5-HT3 receptor antagonist (Ki = 4.5 nM).[3] As of 2009, Lu AA21004 is undergoing phase III clinical trials.[1] An NDA is not expected to be submitted to the FDA until at least 2011.[1]

See also

References

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GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others

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  1. ↑ 1.0 1.1 1.2 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ "Lundbeck's "Serotonin Modulator and Stimulator" Lu AA21004: How Novel? How Good? - GLG News". 
  3. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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