Alnespirone

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Alnespirone
File:Alnespirone.svg
Systematic (IUPAC) name
(+)-4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Identifiers
CAS Number 143413-68-7
ATC code none
PubChem CID 178132
ChemSpider 8002134
Chemical data
Formula C26H38N2O4
Molar mass 442.589 g/mol[[Script error: No such module "String".]]
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Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.[1][2][3] It has antidepressant and anxiolytic effects.[1]

See also

References

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  1. 1.0 1.1 Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice". Neuroreport. 3 (1): 84–86. doi:10.1097/00001756-199201000-00022. PMID 1351756. 
  2. Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists". Psychopharmacology (Berl). 108 (1-2): 47–50. doi:10.1007/BF02245284. PMID 1357709. 
  3. Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity". Eur J Pharmacol. 459 (1): 17–26. doi:10.1016/S0014-2999(02)02814-5. PMID 12505530.