Clovoxamine

Clovoxamine
	File:Clovoxamine.png
Systematic (IUPAC) name
	1-(4-chlorophenyl)-5-methoxypentan-1-one O-2-aminoethyl oxime
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Identifiers
CAS Number	54739-21-8
PubChem	CID 6335903
Chemical data
Formula	C14H21ClN2O2
Molar mass	284.78 g/mol
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Clovoxamine is a drug that was discovered in the 1970s and subsequently investigated as an antidepressant and anxiolytic agent.^[1]^[2]^[3] It acts as a serotonin-norepinephrine reuptake inhibitor (SNRI), with little affinity for the muscarinic acetylcholine, histamine, adrenergic, and serotonin receptors.^[4]^[5] It is structurally related to fluvoxamine.

References

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↑ Freeman; Wakelin, JS; Calanca, A; Hole, G (1982). "Initial clinical evaluation of a new nontricyclic antidepressant: clovoxamine". Advances in biochemical psychopharmacology. 32: 69–75. PMID 7046368. edit
↑ Jesinger; Gostick, N (1989). "Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake". International clinical psychopharmacology. 4 (4): 301–11. doi:10.1097/00004850-198910000-00005. PMID 2691573. edit
↑ Hurst; Jones, DR; Wright, JH; Jarboe, CH (1983). "Clovoxamine kinetics in an early clinical trial". Clinical pharmacology and therapeutics. 34 (2): 266–71. doi:10.1038/clpt.1983.164. PMID 6872422. edit
↑ Saletu; Grünberger, J; Rajna, P; Karobath, M (1980). "Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man". Journal of neural transmission. 49 (1-2): 63–86. doi:10.1007/BF01249190. PMID 6777458. edit
↑ Bradford; Tulp, MT; Schipper, J (1987). "Biochemical effects in rats after acute and long-term treatment with clovoxamine". Archives internationales de pharmacodynamie et de therapie. 287 (2): 188–202. PMID 2820327. edit