Indeloxazine

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Indeloxazine
File:Indeloxazine.svg
Systematic (IUPAC) name
2-(3H-inden-4-yloxymethyl)morpholine
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Biological half-life 2.2 hours
Identifiers
CAS Number 60929-23-9
ATC code none
PubChem CID 3704
Chemical data
Formula C14H17NO2
Molar mass 231.290 g/mol[[Script error: No such module "String".]]
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Indeloxazine (Elen, Noin) is a so-called cerebral activator used in Japan for the treatment of cerebrovascular disease.[1] It was launched in 1988.[2] Indeloxazine acts as a serotonin releasing agent and norepinephrine reuptake inhibitor.[3] It also acts as an NMDA receptor antagonist.[4] It enhances acetylcholine release through indirect activation of the 5-HT4 receptor.[5][6][7] Indeloxazine has nootropic,[8][9][6][7] neuroprotective,[10][11][12][13] anticonvulsant,[14] and antidepressant effects.[15][16][3]

See also

References

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  1. "Index nominum, international drug ... - Google Books". 
  2. "Dictionary of pharmacological agents - Google Books". 
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  8. Ogawa N, Haba K, Sora YH, Higashida A, Sato H, Ogawa S (1988). "Comparison of the effects of bifemelane hydrochloride and indeloxazine hydrochloride on scopolamine hydrobromide-induced impairment in radial maze performance". Clinical Therapeutics. 10 (6): 704–11. PMID 3219685. 
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  12. Shimizu-Sasamata M, Terai M, Harada M, Yamamoto M (1993). "Anti-hypoxic and anti-ischemic actions of indeloxazine hydrochloride and its optical isomers: possible involvement of cerebral energy metabolism". Archives Internationales De Pharmacodynamie Et De Thérapie. 324: 33–46. PMID 8297184. 
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