Piperoxan

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Piperoxan
File:Piperoxan.png
Systematic (IUPAC) name
1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)piperidine
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 59-39-2
135-87-5 (hydrochloride)
ATC code none
PubChem CID 6040
ChemSpider 5817
Chemical data
Formula C14H19NO2
Molar mass 233.31 g/mol[[Script error: No such module "String".]]
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Piperoxan, also known as benodaine or benzodioxane, is a drug which was the very first antihistamine ever to be discovered.[1][2] It was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]

See also

References

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Aminoalkyl ethers
Substituted alkylamines
Substituted ethylenediamines
Phenothiazine derivatives
Piperazine derivatives
Others for systemic use
For topical use
Antiallergic agents excluding corticosteroids
Other antiallergics
fr:Pipéroxane
  1. ↑ 1.0 1.1 1.2 1.3 Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1. 
  2. ↑ 2.0 2.1 2.2 Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9. 
  3. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. ↑ "Daniel Bovet - Biography". 
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