Piperoxan

Piperoxan
	File:Piperoxan.png
Systematic (IUPAC) name
	1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)piperidine
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Identifiers
CAS Number	59-39-2 ; 135-87-5 (hydrochloride)
ATC code	none
PubChem	CID 6040
ChemSpider	5817
Chemical data
Formula	C14H19NO2
Molar mass	233.31 g/mol[[Script error: No such module "String".]]
	Script error: No such module "collapsible list".

Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Piperoxan, also known as benodaine or benzodioxane, is a drug which was the very first antihistamine ever to be discovered.^[1]^[2] It was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.^[1]^[2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.^[1]^[2]^[3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,^[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.^[1]

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

fr:Pipéroxane

↑ ^1.0 ^1.1 ^1.2 ^1.3 Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
↑ ^2.0 ^2.1 ^2.2 Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
↑ "Daniel Bovet - Biography".

[isbn0-941901-21-1-1] 1.0 ^1.1 ^1.2 ^1.3 Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.

[isbn0-7817-6879-9-2] 2.0 ^2.1 ^2.2 Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.

[3] Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.

[urlDaniel_Bovet_-_Biography-4] "Daniel Bovet - Biography".

[1]

[2]

[3]

[4]

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Piperoxan

See also

References

Navigation menu

Views

Personal tools

Navigation

Search

Tools

adverts