Difference between revisions of "Pargyline"

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Pargyline
File:Pargyline.svg
Systematic (IUPAC) name
N-Benzyl-N-methylprop-2-yn-1-amine
Identifiers
CAS Number 555-57-7
ATC code C02KC01 (WHO) C02LL01
PubChem CID 4688
Chemical data
Formula C11H13N
Molar mass 159.23 g/mol[[Script error: No such module "String".]]
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Pargyline (Eutonyl) is a monoamine oxidase B (MAO-B) inhibitor.[1] It has antihypertensive effects.[2]

Pharmacology

It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.[3]

References

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  1. Murphy DL, Karoum F, Pickar D; et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606. 
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  3. Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006