5-I-R91150

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5-I-R91150
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Systematic (IUPAC) name
4-amino-N-[1-[3-(4-fluorophenyl)propyl]-4-methylpiperidin-4-yl]-5-iodo-2-methoxybenzamide
Identifiers
CAS Number 155928-24-8
PubChem CID 132997
Chemical data
Formula C23H29FIN3O2
Molar mass 525.398[[Script error: No such module "String".]]
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5-I-R91150 (or R93274) is a compound that acts as a potent and selective antagonist of 5-HT2A receptors.[1] Its main application is as its iodine-123 radiolabeled form, in which it can be used in SPECT scanning[2] in human neuroimaging studies, to examine the distribution of the 5-HT2A receptor subtype in the brain, e.g. with respect to sex and age[3] and in adults with Asperger syndrome[4] or Alzheimer's disease.[5]

An alternative 5-HT2A receptor ligand also used in neuroimaging is altanserin.

References

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Further reading


  1. Peremans K, Audenaert K, Coopman F, Jacobs F, Dumont F, Slegers G, Verschooten F, van Bree H, Mertens J, Dierckx R. Regional binding index of the radiolabeled selective 5-HT2A antagonist 123I-5-I-R91150 in the normal canine brain imaged with single photon emission computed tomography. Veterinary Radiology & Ultrasound. 2003 May-Jun;44(3):344-51. PMID 12816380
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