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Dimemebfe (N,N-dimethyl-2-(5-methoxybenzofuran-3-yl)ethanamine) is a compound which acts as an agonist for the 5-HT1A and 5-HT2 family of serotonin receptors. It is related in structure to the hallucinogenic tryptamine derivative 5-MeO-DMT, but with the indole nitrogen replaced by oxygen, making dimemebfe a benzofuran derivative. It is several times less potent as a serotonin agonist than 5-MeO-DMT and with relatively more activity at 5-HT1A, but still shows strongest effects at the 5-HT2 family of receptors.
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- Tomaszewski Z, Johnson MP, Huang X, Nichols DE. Benzofuran bioisosteres of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 1992 May 29;35(11):2061-4. PMID 1534585