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F-15,599 is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity by strongly activating 5-HT1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT1A receptor agonist and is being investigated as a novel potential antidepressant.
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