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Systematic (IUPAC) name
Chemical data
Formula C24H27F3N2O2
Molar mass 432.478 g/mol[[Script error: No such module "String".]]
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A-372,159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]


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  1. Childers WE, Robichaud AJ. Recent Advances in Selective Serotonergic Agents. Annual Reports in Medicinal Chemistry 2005; Volume 40:17-33. ISBN 978-0-12-040540-4