SDZ SER-082

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SDZ SER-082
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Systematic (IUPAC) name
(+)-cis 4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine
Identifiers
CAS Number 141474-54-6
PubChem CID 9859407
Chemical data
Formula C15H20N2
Molar mass 228.332 g/mol[[Script error: No such module "String".]]
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SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as cocaine.[5][6][7]

References

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  1. Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. doi:10.1021/jm00001a007
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  6. Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports : PR. 57 (1): 35–46. PMID 15849375. 
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