Pruvanserin
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File:Pruvanserin.png | |
Systematic (IUPAC) name | |
---|---|
7-({4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}carbonyl)-1H-indole-3-carbonitrile | |
Clinical data | |
Routes of administration | Oral |
Legal status | |
Legal status |
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Identifiers | |
CAS Number |
443144-26-1 443144-27-2 (hydrochloride) |
ATC code | none |
PubChem | CID 6433122 |
ChemSpider | 4938310 |
Chemical data | |
Formula | C22H21FN4O |
Molar mass | 376.43 g/mol[[Script error: No such module "String".]] |
Script error: No such module "collapsible list". | |
Pruvanserin (EMD-281,014, LY-2,422,347) is a selective 5-HT2A receptor antagonist which was under development by Eli Lilly for the treatment of insomnia.[1][2] It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company's development pipeline.[3][4] In addition to its sleep-improving properties,[5][6] pruvanserin has also been shown to have antidepressant, anxiolytic, and working memory-enhancing effects in animal studies.[7][8][9]
See also
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–76. PMID 18673166. CS1 maint: Multiple names: authors list (link)
- ↑ "Efficacy Study of LY2422347 to Treat Insomnia - Full Text View - ClinicalTrials.gov".
- ↑ "Eli Lilly and Company » Research Pipeline".
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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