Pruvanserin

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Pruvanserin
File:Pruvanserin.png
Systematic (IUPAC) name
7-({4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}carbonyl)-1H-indole-3-carbonitrile
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 443144-26-1
443144-27-2 (hydrochloride)
ATC code none
PubChem CID 6433122
ChemSpider 4938310
Chemical data
Formula C22H21FN4O
Molar mass 376.43 g/mol[[Script error: No such module "String".]]
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Pruvanserin (EMD-281,014, LY-2,422,347) is a selective 5-HT2A receptor antagonist which was under development by Eli Lilly for the treatment of insomnia.[1][2] It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company's development pipeline.[3][4] In addition to its sleep-improving properties,[5][6] pruvanserin has also been shown to have antidepressant, anxiolytic, and working memory-enhancing effects in animal studies.[7][8][9]

See also

References

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  2. Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–76. PMID 18673166. 
  3. "Efficacy Study of LY2422347 to Treat Insomnia - Full Text View - ClinicalTrials.gov". 
  4. "Eli Lilly and Company » Research Pipeline". 
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