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Systematic (IUPAC) name
CAS Number 152239-46-8
PubChem CID 3277600
Synonyms SB-204,741
Chemical data
Formula C14H14N4OS
Molar mass 286.352 g/mol[[Script error: No such module "String".]]
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SB-204,741 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 135x selectivity over the closely related 5-HT2C receptor, and even higher over the 5-HT2A receptor and other targets.[1] It is used in scientific research for investigating the functions of the 5-HT2B receptor.[2][3][4][5]


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  1. Forbes IT, Jones GE, Murphy OE, Holland V, Baxter GS. N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist. Journal of Medicinal Chemistry. 1995 Mar 17;38(6):855-7. PMID 7699699
  2. Glusa E, Pertz HH. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors. British Journal of Pharmacology. 2000 Jun;130(3):692-8. PMID 10821800
  3. Holohean AM, Hackman JC. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. British Journal of Pharmacology. 2004 Oct;143(3):351-60. PMID 15339859
  4. Papageorgiou A, Denef C. Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. 2007 Sep;148(9):4509-22. PMID 17584957
  5. Wouters MM, Gibbons SJ, Roeder JL, Distad M, Ou Y, Strege PR, Szurszewski JH, Farrugia G. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology. 2007 Sep;133(3):897-906. PMID 17854596